Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection.

Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection. Research Abstract Details 

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Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection. Abstract Text:

P Kintz,P Mangin,A A Lugnier,A J Chaumont,

A capillary column gas chromatographic method is described for the simultaneous determination of morphine, codeine, heroin, 3- and 6-monoacetylmorphine, nalorphine, naloxone, ethylmorphine, and naltrexone. The drugs were extracted from 2 ml plasma, urine, or other biological samples, including tissue under alkaline conditions in chloroform-isopropanol-n-heptane (50:17:33, v/v), with levallorphan as an internal standard. The drugs were extracted into acid and then reextracted into chloroform after the acid had been alkalinized. After derivatization with trifluoroacetic anhydride, an aliquot was injected into a 25m capillary column equipped with a nitrogen phosphorus detector. The lower limits of detectability, extraction recovery, and the within-run and day-to-day precision of results were determined for each drug. Our results indicate that the procedure is suitable for use in overdose screening and therapeutic drug monitoring.

Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection. Publishing Authors By Initials

P Kintz,P Mangin,AA Lugnier,AJ Chaumont,

For similar disorders of environmental origin: substance-related disorders: opioid-related disorders research abstracts see: disorders of environmental origin: substance-related disorders: opioid-related disorders research

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Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zeitschrift für Rechtsmedizin. Journal of legal me

VOLUME: 103

Page Numbers: 57-62

Journal Abbreviation: Z. Rechtsmed.

ISSN: 0044-3433

DAY: 20

MONTH: 02

YEAR: 1989

Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection. Information

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LANGUAGE: eng

NlmUniqueID: 247437

Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection. Keywords Mesh Terms:

KEYWORDS: Opioid-Related Disorders

MESH TERMS: rehabilitation

Chemical & Substance for Abstract: Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection. Information

Substance Name: Nalorphine

Registry Number: 62-67-9

Grant and Affiliation Information for Simultaneous identification and quantification of several opiates and derivatives by capillary gas chromatography and nitrogen selective detection.

AFFILIATION: Institut de Médecine Légale, Strasbourg, France.

Country: GERMANY, WEST

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MEDLINETA: Z Rechtsmed

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