Simultaneous determination of cefepime and L-arginine by micellar electrokinetic chromatography and applications to commercial injections.

Simultaneous determination of cefepime and L-arginine by micellar electrokinetic chromatography and applications to commercial injections. Research Abstract Details 

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Simultaneous determination of cefepime and L-arginine by micellar electrokinetic chromatography and applications to commercial injections. Abstract Text:

Yi-Ru Chen,Shun-Jin Lin,Yu-Wei Chou,Hsin-Lung Wu,Su-Hwei Chen,Yi-Ru Chen,Shun-Jin Lin,Yu-Wei Chou,Hsin-Lung Wu,Su-Hwei Chen,

A simple micellar electrokinetic chromatography (MEKC) with UV detection is described for simultaneous analysis of cefepime and L-arginine. The determination of cefepime and L-arginine in pharmaceutical preparations was performed at 25degreesC using a background electrolyte consisting of Tris buffer with sodium dodecyl sulfate (SDS) as the electrolyte solution. Several parameters affecting the separation of the drugs were studied, including the pH and concentrations of the Tris buffer and SDS. Under optimal MEKC conditions, good separation with high efficiency and short analysis times is achieved. Using cefazolin as an internal standard, the linear ranges of the method for the determination of cefepime and L-arginine were over 5-100 microg/mL; the detection limits of cefepime (signal to noise ratio = 3; injection 3.45 kPa, 3 s) and L-arginine (signal to noise ratio = 3; injection 3.45 kPa, 3 s) were 2 microg/mL and 4 microg/ mL, respectively. Applicability of the proposed method for the determination of cefepime and L-arginine in commercial injections was demonstrated.

Simultaneous determination of cefepime and L-arginine by micellar electrokinetic chromatography and applications to commercial injections. Publishing Authors By Initials

YR Chen,SJ Lin,YW Chou,HL Wu,SH Chen,YR Chen,SJ Lin,YW Chou,HL Wu,SH Chen,

For similar organic chemicals: alcohols: glycols: propylene glycols: tromethamine research abstracts see: organic chemicals: alcohols: glycols: propylene glycols: tromethamine research

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Simultaneous determination of cefepime and L-arginine by micellar electrokinetic chromatography and applications to commercial injections. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of separation science

VOLUME: 28

Page Numbers: 2173-9

Journal Abbreviation:

ISSN: 1615-9306

DAY: 1

MONTH: Nov

YEAR: 2005

Simultaneous determination of cefepime and L-arginine by micellar electrokinetic chromatography and applications to commercial injections. Information

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LANGUAGE: eng

NlmUniqueID: 101088554

Simultaneous determination of cefepime and L-arginine by micellar electrokinetic chromatography and applications to commercial injections. Keywords Mesh Terms:

KEYWORDS: Tromethamine

MESH TERMS: standards

Chemical & Substance for Abstract: Simultaneous determination of cefepime and L-arginine by micellar electrokinetic chromatography and applications to commercial injections. Information

Substance Name: cefepime

Registry Number: 88040-23-7

Grant and Affiliation Information for Simultaneous determination of cefepime and L-arginine by micellar electrokinetic chromatography and applications to commercial injections.

AFFILIATION: Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan.

Country: Germany

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MEDLINETA: J Sep Sci

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