Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma.

Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma. Research Abstract Details 

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Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma. Abstract Text:

Wonku Kang,Ji-Hoon Jeong,Eunsook Ma,Kwang-il Kwon,

A simple and rapid quantification method was developed for determining menatetrenone and its epoxide metabolite in human plasma. After a simple protein precipitation with methanol, the analytes were chromatographed on a reversed-phase C(18) column and detected by LC/MS/MS with atmospheric pressure chemical ionization. The coefficient of variation of the assay precision was less than 10.1%, and the accuracy ranged from 98.0 to 106.5%. The limit of detection of menatetrenone and its epoxide was 0.5 and 0.2 ng/ml, respectively. This method was used to simultaneously measure the plasma concentration of menatetrenone and its epoxide metabolite from healthy subjects after a single 30 mg oral dose of menatetrenone.

Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma. Publishing Authors By Initials

W Kang,JH Jeong,E Ma,KI Kwon,

For similar organic chemicals: hydrocarbons: hydrocarbons, cyclic: hydrocarbons, aromatic: polycyclic hydrocarbons, aromatic: naphthalenes: naphthoquinones: vitamin k: vitamin k 2 research abstracts see: organic chemicals: hydrocarbons: hydrocarbons, cyclic: hydrocarbons, aromatic: polycyclic hydrocarbons, aromatic: naphthalenes: naphthoquinones: vitamin k: vitamin k 2 research

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Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 44

Page Numbers: 1178-82

Journal Abbreviation:

ISSN: 0731-7085

DAY: 29

MONTH: 04

YEAR: 2007

Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8309336

Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma. Keywords Mesh Terms:

KEYWORDS: Vitamin K 2

MESH TERMS: metabolism

Chemical & Substance for Abstract: Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma. Information

Substance Name: menatetrenone

Registry Number: 863-61-6

Grant and Affiliation Information for Simple and sensitive determination of menatetrenone and its epoxide metabolite in human plasma.

AFFILIATION: College of Pharmacy, Catholic University of Daegu, Kyoungbuk 712-702, South Korea.

Country: England

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MEDLINETA: J Pharm Biomed Anal

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