Simple 1H NMR spectroscopic method for assay of salts of the contrast agent diatrizoate in commercial solutions.

Simple 1H NMR spectroscopic method for assay of salts of the contrast agent diatrizoate in commercial solutions. Research Abstract Details 

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Simple 1H NMR spectroscopic method for assay of salts of the contrast agent diatrizoate in commercial solutions. Abstract Text:

A simple, accurate, and specific 1H NMR spectroscopic method was developed for the assay of diatrizoate meglumine or the combination diatrizoate meglumine and diatrizoate sodium in commercial solutions for injection. A mixture of injectable solution and sodium acetate, the internal standard, was diluted with D2O and the 1H NMR spectrum of the solution was obtained. Two approaches were used to calculate the drug content, based on the integral values for the -N-CO-CH3 protons of diatrizoic acid at 2.23 ppm, and -N-CH3 protons of meglumine at 2.73 ppm, and the CH3-CO-protons of sodium acetate at 1.9 ppm. Recoveries (mean +/- standard deviation) of diatrizoic acid and meglumine from 10 synthetic mixtures of various amounts of these compounds with a fixed amount of internal standard were 100.3 +/- 0.55% and 100.1 +/- 0.98%, respectively. In addition to providing a direct means of simultaneously assaying diatrizoic acid and meglumine, the proposed NMR method can also be used to identify diatrizoate meglumine and each of its molecular components.

Simple 1H NMR spectroscopic method for assay of salts of the contrast agent diatrizoate in commercial solutions. Publishing Authors By Initials

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Simple 1H NMR spectroscopic method for assay of salts of the contrast agent diatrizoate in commercial solutions. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of AOAC International

VOLUME: 79

Page Numbers: 833-8

Journal Abbreviation: J AOAC Int

ISSN: 1060-3271

DAY: 17

MONTH: 03

YEAR: 2008

Simple 1H NMR spectroscopic method for assay of salts of the contrast agent diatrizoate in commercial solutions. Information

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LANGUAGE: eng

NlmUniqueID: 9215446

Simple 1H NMR spectroscopic method for assay of salts of the contrast agent diatrizoate in commercial solutions. Keywords Mesh Terms:

KEYWORDS: Solutions

MESH TERMS: chemistry

Chemical & Substance for Abstract: Simple 1H NMR spectroscopic method for assay of salts of the contrast agent diatrizoate in commercial solutions. Information

Substance Name: Meglumine

Registry Number: 6284-40-8

Grant and Affiliation Information for Simple 1H NMR spectroscopic method for assay of salts of the contrast agent diatrizoate in commercial solutions.

AFFILIATION: US Food and Drug Administration, Northeast Regional Laboratory, Brooklyn, NY 11232, USA.

Country: UNITED STATES

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MEDLINETA: J AOAC Int

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