Simian varicella virus gene 61 encodes a viral transactivator but is non-essential for in vitro replication.

Simian varicella virus gene 61 encodes a viral transactivator but is non-essential for in vitro replication. Research Abstract Details 

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Simian varicella virus gene 61 encodes a viral transactivator but is non-essential for in vitro replication. Abstract Text:

W L Gray,K Davis,Y Ou,C Ashburn,T M Ward,

Simian varicella virus (SVV) is closely related to varicella-zoster virus (VZV), the causative agent of chickenpox and shingles. The SVV and VZV gene 61 polypeptides are homologs of the HSV-1 ICP0, a viral transactivator which appears to play a role in viral latency and reactivation. In this study, the molecular properties of the SVV 61 were characterized. The SVV open reading frame (ORF) 61 encodes a 54.1-kDa polypeptide with 37% amino acid identity to the VZV 61. Homology to the HSV-1 ICP-0 is limited to a conserved RING finger motif at the amino terminus of the protein. A nuclear localization sequence (nls) at the carboxy-terminus directs the SVV 61 to the cell nucleus, while a SVV 61nls(-) mutant is confined to the cell cytoplasm. The SVV 61 transactivates its own promoter as well as SVV immediate early (IE, ORF 62), early (ORFs 28 and 29), and late (ORF 68) gene promoters in transfected Vero cells. The RING finger and nls motifs are required for efficient SVV 61 transactivation. The SVV 61 has no effect on the ability of the major SVV transactivator (IE62) to induce SVV promoters. Generation and propagation of a SVV gene 61 deletion mutant demonstrated that the SVV 61 is non-essential for in vitro replication. SVV gene 61 is expressed in liver, lung, and neural ganglia of infected monkeys during acute simian varicella.

Simian varicella virus gene 61 encodes a viral transactivator but is non-essential for in vitro replication. Publishing Authors By Initials

WL Gray,K Davis,Y Ou,C Ashburn,TM Ward,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research

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Simian varicella virus gene 61 encodes a viral transactivator but is non-essential for in vitro replication. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Archives of virology

VOLUME: 152

Page Numbers: 553-63

Journal Abbreviation: Arch. Virol.

ISSN: 0304-8608

DAY: 20

MONTH: 11

YEAR: 2006

Simian varicella virus gene 61 encodes a viral transactivator but is non-essential for in vitro replication. Information

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LANGUAGE: eng

NlmUniqueID: 7506870

Simian varicella virus gene 61 encodes a viral transactivator but is non-essential for in vitro replication. Keywords Mesh Terms:

KEYWORDS: Virus Replication

MESH TERMS: physiology

Chemical & Substance for Abstract: Simian varicella virus gene 61 encodes a viral transactivator but is non-essential for in vitro replication. Information

Substance Name: Trans-Activators

Registry Number: 0

Grant and Affiliation Information for Simian varicella virus gene 61 encodes a viral transactivator but is non-essential for in vitro replication.

AFFILIATION: Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. graywaynel@uams.edu

Country: Austria

AGENCY: United States NIAID

GRANT: AI052373

ACRONYM: AI

MEDLINETA: Arch Virol

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