Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys.

Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys. Abstract Text:

L E Pereira,F Villinger,N Onlamoon,P Bryan,A Cardona,K Pattanapanysat,K Mori,S Hagen,L Picker,A A Ansari,

Differences in clinical outcome of simian immunodeficiency virus (SIV) infection in disease-resistant African sooty mangabeys (SM) and disease-susceptible Asian rhesus macaques (RM) prompted us to examine the role of regulatory T cells (Tregs) in these two animal models. Results from a cross-sectional study revealed maintenance of the frequency and absolute number of peripheral Tregs in chronically SIV-infected SM while a significant loss occurred in chronically SIV-infected RM compared to uninfected animals. A longitudinal study of experimentally SIV-infected animals revealed a transient increase in the frequency of Tregs from baseline values following acute infection in RM, but no change in the frequency of Tregs occurred in SM during this period. Further examination revealed a strong correlation between plasma viral load (VL) and the level of Tregs in SIV-infected RM but not SM. A correlation was also noted in SIV-infected RM that control VL spontaneously or in response to antiretroviral chemotherapy. In addition, immunofluorescent cell count assays showed that while Treg-depleted peripheral blood mononuclear cells from RM led to a significant enhancement of CD4+ and CD8+ T-cell responses to select pools of SIV peptides, there was no detectable T-cell response to the same pool of SIV peptides in Treg-depleted cells from SIV-infected SM. Our data collectively suggest that while Tregs do appear to play a role in the control of viremia and the magnitude of the SIV-specific immune response in RM, their role in disease resistance in SM remains unclear.

Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys. Publishing Authors By Initials

LE Pereira,F Villinger,N Onlamoon,P Bryan,A Cardona,K Pattanapanysat,K Mori,S Hagen,L Picker,AA Ansari,

For similar virus diseases: viremia research abstracts see: virus diseases: viremia research

PUBMED ID PMID:

MEDLINE DATE:

Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of virology

VOLUME: 81

Page Numbers: 4445-56

Journal Abbreviation:

ISSN: 0022-538X

DAY: 21

MONTH: 02

YEAR: 2007

Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys. Keywords Mesh Terms:

KEYWORDS: Viremia

MESH TERMS: immunology

Chemical & Substance for Abstract: Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys.

AFFILIATION: Department of Pathology and Lab Medicine, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30329, USA.

Country: United States

AGENCY: United States PHS

GRANT: R01 27057

ACRONYM:

MEDLINETA: J Virol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Simian immunodeficiency virus SIV infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys Related Publications

• A TAD further: exogenous control of gene activation.
• A new method of assessing pathological elastin degradation in the horse.
• A robust method to estimate time split in second heart sound using instantaneous frequency analysis.
• A simple method for fabricating occlusal rests in interim partial denture clasps.
• Application of fractional factorial design and Doehlert matrix in the optimization of experimental variables associated with the ultrasonic-assisted acid digestion of chocolate samples for aluminum determination by atomic absorption spectrometry.
• CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species: involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation.
• Differential immune responses to albumin adducts of reactive intermediates of trichloroethene in MRL+/+ mice.
• Dorsal onlay buccal mucosa versus penile skin flap urethroplasty for anterior urethral strictures: results from a randomized prospective trial.
• Evaluation of the effect of extra-amniotic normal saline infusion alone or in combination with dexamethasone for the induction of labor.
• Fatty acids of unusual double-bond positions and chain lengths found in rat skin surface lipids.
• Fever work-up and management in postsurgical oral and maxillofacial surgery patients.
• Hormonal profiles and biochemical indices of bone turnover in Indian women.
• Immunosuppression as therapy for congestive heart failure.
• Impaired parietal magnitude processing in developmental dyscalculia.
• Katz and Ansari Respond: Released Nuclear Medicine Patients, Security Checkpoints, and the NRC.
• Letter to the Editor: Vitiligo: auto-immunity and immune responses.
• Lung cancer in bahrain (1952-2004).
• Maintenance of CD4(+) T cell TCR Vbeta repertoire heterogeneity is characteristic of apathogenic SIV infection in non-human primate model of AIDS.
• Methyl palmitate inhibits lipopolysaccharide-stimulated phagocytic activity of rat peritoneal macrophages.
• Organ donation: ethics.
• Pathogenic and apathogenic courses of SIV infection are associated with distinct and characteristic regulatory patterns of G1/S and G2/M cell cycle checkpoints in CD4+ T cells.
• Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques.
• Retroperitoneoscopic adrenalectomy for phaeochromocytoma in a morbidly obese patient: a case report.
• SDS-polyacrylamide gel electrophoresis of buffalo bulls seminal plasma proteins and their relation with semen freezability.
• Salivary gland tumors in an Iranian population: a retrospective study of 130 cases.
• Searching for optimal frame patterns in an integrated TDMA communication system using mean field annealing.
• Simian immunodeficiency virus (SIV) infection influences the level and function of regulatory T cells in SIV-infected rhesus macaques but not SIV-infected sooty mangabeys.
• Structure and properties of generalized adaptive neural filters for signal enhancement.
• Survey of patient release information on radiation and security checkpoints.
• Toward artificial developmental regulators.