Silicone derivatives for contact lenses: functionalization, chemical characterization, and cell compatibility assessment.

Silicone derivatives for contact lenses: functionalization, chemical characterization, and cell compatibility assessment. Research Abstract Details 

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Silicone derivatives for contact lenses: functionalization, chemical characterization, and cell compatibility assessment. Abstract Text:

V Migonney,M D Lacroix,B D Ratner,M Jozefowicz,

Epoxy ring-opening functionalization of polymers at random sites along chains with various chemical groups has been demonstrated. The reaction is performed in an aqueous solution under mild conditions in order to minimize degradation of the macromolecular chains. Silicone lenses made of copolymers with epoxy side chains were functionalized with 4-hydroxybutyric acid, sodium salt. The carboxylated silicone derivatives were characterized by ESCA and radiotracers. A mean value of 30% reaction yield was concluded, based upon data from both methods; nevertheless, the latter can be improved up to 50% or more if the conditions of preparation of the epoxydized silicone lenses are optimized. Derivatized silicones were coated in the wells of culture plates to evaluate the cell compatibility of these new polymers with a fibroblast cell line (McCoy's). No cellular toxicity was observed.

Silicone derivatives for contact lenses: functionalization, chemical characterization, and cell compatibility assessment. Publishing Authors By Initials

V Migonney,MD Lacroix,BD Ratner,M Jozefowicz,

For similar organic chemicals: carboxylic acids: acids, acyclic: butyric acids: 3-hydroxybutyric acid: hydroxybutyrates: sodium oxybate research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: butyric acids: 3-hydroxybutyric acid: hydroxybutyrates: sodium oxybate research

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Silicone derivatives for contact lenses: functionalization, chemical characterization, and cell compatibility assessment. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 7

Page Numbers: 265-75

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 1995

Silicone derivatives for contact lenses: functionalization, chemical characterization, and cell compatibility assessment. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007393

Silicone derivatives for contact lenses: functionalization, chemical characterization, and cell compatibility assessment. Keywords Mesh Terms:

KEYWORDS: Sodium Oxybate

MESH TERMS: chemistry

Chemical & Substance for Abstract: Silicone derivatives for contact lenses: functionalization, chemical characterization, and cell compatibility assessment. Information

Substance Name: Sodium Oxybate

Registry Number: 502-85-2

Grant and Affiliation Information for Silicone derivatives for contact lenses: functionalization, chemical characterization, and cell compatibility assessment.

AFFILIATION: Laboratoire de Recherches sur les Macromolécules, CNRS URA 502, Institut Galilée, Université Paris-Nord, Villetaneuse.

Country: NETHERLANDS

AGENCY: United States NCRR

GRANT: RR01296

ACRONYM: RR

MEDLINETA: J Biomater Sci Polym Ed

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