Silent synapses in developing rat nucleus tractus solitarii have AMPA receptors.

Silent synapses in developing rat nucleus tractus solitarii have AMPA receptors. Research Abstract Details 

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Silent synapses in developing rat nucleus tractus solitarii have AMPA receptors. Abstract Text:

NMDA-only synapses, called silent synapses, are thought to be the initial step in synapse formation in several systems. However, the underlying mechanism and the role in circuit construction are still a matter of dispute. Using combined morphological and electrophysiological approaches, we searched for silent synapses at the level of the nucleus tractus solitarii (NTS), a brainstem structure that is a gateway for many visceral sensory afferent fibers. Silent synapses were detected at birth by using electrophysiological recordings and minimal stimulation protocols. However, anatomical experiments indicated that nearly all, if not all, NTS synapses had AMPA receptors. Based on EPSC fluctuation measurements and differential blockade by low-affinity competitive and noncompetitive glutamate antagonists, we then demonstrated that NTS silent synapses were better explained by glutamate spillover from neighboring fibers and/or slow dynamic of fusion pore opening. Glutamate spillover at immature NTS synapses may favor crosstalk between active synapses during development when glutamate transporters are weakly expressed and contribute to synaptic processing as well as autonomic circuit formation.

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Silent synapses in developing rat nucleus tractus solitarii have AMPA receptors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of neuroscience : the official journal

VOLUME: 28

Page Numbers: 4624-34

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 30

MONTH: Apr

YEAR: 2008

Silent synapses in developing rat nucleus tractus solitarii have AMPA receptors. Information

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LANGUAGE: eng

NlmUniqueID: 8102140

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Grant and Affiliation Information for Silent synapses in developing rat nucleus tractus solitarii have AMPA receptors.

AFFILIATION: Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6231, Université Paul Cézanne, Université de la Méditerranée, Faculté de Médecine, 13916 Marseille cedex 20, France.

Country: United States

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MEDLINETA: J Neurosci

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