Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.

Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Abstract Text:

Sergei Musatov,Walter Chen,Donald W Pfaff,Charles V Mobbs,Xue-Jun Yang,Deborah J Clegg,Michael G Kaplitt,Sonoko Ogawa,

Estrogen receptor alpha (ERalpha) plays a pivotal role in the regulation of food intake and energy expenditure by estrogens. Although it is well documented that a disruption of ERalpha signaling in ERalpha knockout (ERKO) mice leads to an obese phenotype, the sites of estrogen action and mechanisms underlying this phenomenon are still largely unknown. In the present study, we exploited RNA interference mediated by adeno-associated viral vectors to achieve focused silencing of ERalpha in the ventromedial nucleus of the hypothalamus, a key center of energy homeostasis. After suppression of ERalpha expression in this nucleus, female mice and rats developed a phenotype characteristic for metabolic syndrome and marked by obesity, hyperphagia, impaired tolerance to glucose, and reduced energy expenditure. This phenotype persisted despite normal ERalpha levels elsewhere in the brain. Although an increase in food intake preceded weight gain, our data suggest that a leading factor of obesity in this model is likely a decline in energy expenditure with all three major constituents being affected, including voluntary activity, basal metabolic rate, and diet-induced thermogenesis. Together, these findings indicate that ERalpha in the ventromedial nucleus of the hypothalamus neurons plays an essential role in the control of energy balance and the maintenance of normal body weight.

Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Publishing Authors By Initials

S Musatov,W Chen,DW Pfaff,CV Mobbs,XJ Yang,DJ Clegg,MG Kaplitt,S Ogawa,

For similar hypothalamus, middle: ventromedial hypothalamic nucleus research abstracts see: hypothalamus, middle: ventromedial hypothalamic nucleus research

PUBMED ID PMID:

MEDLINE DATE:

Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 2501-6

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 6

MONTH: 02

YEAR: 2007

Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Keywords Mesh Terms:

KEYWORDS: Ventromedial Hypothalamic Nucleus

MESH TERMS: physiology

Chemical & Substance for Abstract: Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Information

Substance Name: Estrogen Receptor alpha

Registry Number: 0

Grant and Affiliation Information for Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.

AFFILIATION: Neurologix, Inc., Fort Lee, NJ 07024, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH67775

ACRONYM: MH

MEDLINETA: Proc Natl Acad Sci U S A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome Related Publications

• A role for proteoglycans in mineralized tissue-titanium adhesion.
• A simple and rapid method for cryopreservation of mouse 2-cell embryos by vitrification: Beneficial effect of sucrose and raffinose on their cryosurvival rate.
• Accumulation and fate of green fluorescent labeled Escherichia coli in laboratory-scale drinking water biofilters.
• An efficient method for sonication assisted Agrobacterium-mediated transformation of coat protein (CP) coding genes into papaya (Carica papaya L.).
• An fMRI study of the functional distinction of neuronal circuits at the sites on ventral visual stream co-activated by visual stimuli of different objects.
• Cardiac cell therapy and arrhythmias.
• Changing concepts of bladder regeneration.
• Detection and identification of Brettanomyces/Dekkera sp. yeasts with a loop-mediated isothermal amplification method.
• Do children with tuberous sclerosis complex have superior musical skill?--A unique tendency of musical responsiveness in children with TSC.
• From gene networks underlying sex determination and gonadal differentiation to the development of neural networks regulating sociosexual behavior.
• Genetic analysis of multifocal superficial urothelial cancers by array-based comparative genomic hybridisation.
• Glycosaminoglycan degradation reduces mineralized tissue-titanium interfacial strength.
• Human defensins and cathelicidins in the skin: beyond direct antimicrobial properties.
• Hypoxia-mediated induction of heme oxygenase type I and carbon monoxide release from astrocytes protects nearby cerebral neurons from hypoxia-mediated apoptosis.
• Impact of improvement in specificity of primary screening test on total cost of prostate cancer mass screening.
• Impacts of diclidophorid monogenean infections on fisheries in Japan.
• Incorporating electron-transfer functionality into synthetic metalloproteins from the bottom-up.
• Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid.
• Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation.
• Osteoinduction by recombinant human bone morphogenetic protein-2 in muscles of non-human primates.
• Oxalate synthesis from hydroxypyruvate in vitamin-B6-deficient rats.
• P21-activated kinase 1: a new molecular marker for intravesical recurrence after transurethral resection of bladder cancer.
• Postulated role of interdomain interaction between regions 1 and 2 within type 1 ryanodine receptor in the pathogenesis of porcine malignant hyperthermia.
• Production of functional spermatids from mouse germline stem cells in ectopically reconstituted seminiferous tubules.
• Production of normal piglets from microsurgically split morulae and blastocysts.
• Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome.
• Solitary upper ureteral malakoplakia successfully diagnosed by ureteroscopic biopsy and treated conservatively.
• Synergy of interferon-alpha and 5-fluorouracil in human renal cell carcinoma requires p53 activity.
• The survival of whole and bisected rabbit morulae after cryopreservation by the vitrification method.
• Ventricular septal rupture masquerading as coronary perforation during intervention for acute myocardial infarction.