Significance of morphological alteration by portal vein branch ligation in endotoxin-induced liver injury after partial hepatectomy.

Significance of morphological alteration by portal vein branch ligation in endotoxin-induced liver injury after partial hepatectomy. Research Abstract Details 

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Significance of morphological alteration by portal vein branch ligation in endotoxin-induced liver injury after partial hepatectomy. Abstract Text:

Shigeyasu Ota,Shohachi Suzuki,Takanori Sakaguchi,Satoshi Baba,Hiroshi Mitsuoka,Satoshi Nakamura,Hiroyuki Konno,Shigeyasu Ota,Shohachi Suzuki,Takanori Sakaguchi,Satoshi Baba,Hiroshi Mitsuoka,Satoshi Nakamura,Hiroyuki Konno,

BACKGROUND: Regenerating liver after partial hepatectomy (PH) is susceptible to endotoxin. This study was conducted to investigate how morphological alteration by preoperative portal vein branch ligation (PVL) affects endotoxin-induced liver injury after PH. METHODS: Male Sprague-Dawley rats were divided into a PVL group undergoing left PVL and into a non-PVL group receiving a sham operation. Seven days later, animals in both groups were subjected to PH (the left lateral, median and caudate lobes). Lipopolysaccharide (LPS) was intravenously administered to both groups 2 days after PH. RESULTS: A significant increase in hepatocyte and sinusoidal endothelial cell proliferation assessed by Ki-67 immunostaining reached a peak at day 2 and 3 after PVL, respectively, in accordance with the changes in plasma interleukin-6 concentrations after PVL. The proliferation response of these cells after PH was observed in both groups, showing a significantly weaker response in the PVL group. The sinusoidal width after PH was significantly reduced in the non-PVL group when compared with that in the PVL group. LPS administration induced a marked elevation of plasma tumour necrosis factor-alpha levels in the non-PVL group compared with the PVL group. PVL before PH significantly attenuated endotoxin-induced functional and structural liver damage with greater hepatic polymorphonuclear leucocyte infiltration and microcirculatory derangement, resulting in an improvement in the 7-day survival rate. CONCLUSIONS: Morphological alteration by PVL is of great advantage in preventing the development of endotoxin-induced liver injury in the regeneration process after PH.

Significance of morphological alteration by portal vein branch ligation in endotoxin-induced liver injury after partial hepatectomy. Publishing Authors By Initials

S Ota,S Suzuki,T Sakaguchi,S Baba,H Mitsuoka,S Nakamura,H Konno,S Ota,S Suzuki,T Sakaguchi,S Baba,H Mitsuoka,S Nakamura,H Konno,

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Significance of morphological alteration by portal vein branch ligation in endotoxin-induced liver injury after partial hepatectomy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Liver international : official journal of the Inte

VOLUME: 27

Page Numbers: 1076-85

Journal Abbreviation: Liver Int.

ISSN: 1478-3223

DAY: 11

MONTH: Oct

YEAR: 2007

Significance of morphological alteration by portal vein branch ligation in endotoxin-induced liver injury after partial hepatectomy. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Significance of morphological alteration by portal vein branch ligation in endotoxin-induced liver injury after partial hepatectomy.

AFFILIATION: Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan. sota@hama-med.ac.jp

Country: England

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MEDLINETA: Liver Int

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