[Significance of microvascular density and vascular endothelial growth factor in breast cancer]

[Significance of microvascular density and vascular endothelial growth factor in breast cancer] Research Abstract Details 

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[Significance of microvascular density and vascular endothelial growth factor in breast cancer] Abstract Text:

Jie Li,San-tai Song,Ze-fei Jiang,Xiao-qing Liu,Ling-di Yan,

OBJECTIVE: To study the significance of vascular endothelial growth factor (VEGF) and microvascular density (MVD) expression in breast cancer. METHODS: The expression of MVD and VEGF was studied in 81 patients with primary breast cancer by SP immunohistochemical technique. RESULTS: There were 49 patients with high VEGF expression (60.5%) and 35 patients with high MVD expression (43.2%). There was significant correlation between VEGF or MVD expression and TNM stage, but not age, tumor size, ER expression or lymph node status. VEGF was significantly related with MVD expression. Univariate analysis showed that patients with low expression of VEGF and MVD had longer disease free survival (DFS) and overall survival (OS). Grouping univariate analysis showed that VEGF had significant correlation with the DFS of all grouped patients and the OS of patients with LN(+) or stage III lesions. MVD had significant correlation with the DFS and OS of LN(+) patients and the DFS of stage III lesion patients. Multivariate analysis showed that MVD was a risk predictor because of its positive statistic value, the higher expression, the shorter survival time of the patients. CONCLUSION: Both VEGF and MVD are useful prognostic factors in breast cancer. MVD appears to be a strong and independent biologic marker for breast cancer prognosis.

[Significance of microvascular density and vascular endothelial growth factor in breast cancer] Publishing Authors By Initials

J Li,ST Song,ZF Jiang,XQ Liu,LD Yan,

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[Significance of microvascular density and vascular endothelial growth factor in breast cancer] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua zhong liu za zhi [Chinese journal of onco

VOLUME: 25

Page Numbers: 145-8

Journal Abbreviation: Zhonghua Zhong Liu Za Zhi

ISSN: 0253-3766

DAY: 10

MONTH: Mar

YEAR: 2003

[Significance of microvascular density and vascular endothelial growth factor in breast cancer] Information

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LANGUAGE: chi

NlmUniqueID: 7910681

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Grant and Affiliation Information for [Significance of microvascular density and vascular endothelial growth factor in breast cancer]

AFFILIATION: Department of Breast Cancer, 307 Hospital, Academy of Military Medical Sciences, Beijing 100850, China.

Country: China

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MEDLINETA: Zhonghua Zhong Liu Za Zhi

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