Significance of kallikrein-kinin system in otitis media with effusion.

Significance of kallikrein-kinin system in otitis media with effusion. Research Abstract Details 

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Significance of kallikrein-kinin system in otitis media with effusion. Abstract Text:

Y Hamaguchi,Y Majima,K Ukai,Y Sakakura,Y Miyoshi,

Significance of the kallikrein-kinin system in the pathogenesis of otitis media with effusion (OME) was evaluated by prekallikrein level, kallikrein activity, and concentration of high molecular weight (HMW) kininogen in 45 middle ear effusions (MEEs, 38 serous and seven mucoid). All MEEs had varying prekallikrein levels (73.1 +/- 127.5 relative fluoro units [RFU]), and the mean value in serous effusions (82.2 RFU) was much higher than that in mucoid effusions (23.0 RFU). Hydrolytic activity of kallikrein in serous effusions was 18.0 +/- 27.9 RFU, and was significantly higher than that in mucoid effusions (8.0 +/- 4.2 RFU, p less than 0.05). Concentration of HMW kininogen in serous effusions was 51.2 +/- 72.77% of plasma value, but it could not be detected in any mucoid effusions. Analysis of protein composition by polyacrylamide gel electrophoresis indicates that plasma protein that has leaked into the middle ear is a major component of MEEs. The kallikrein-kinin system would be active in serous effusions, and liberated bradykinin enhances vascular permeability in the middle ear mucosa, leading to profuse plasma leakage, which characterizes the component of serous effusions. On the other hand, this system would almost be consumed in mucoid effusions.

Significance of kallikrein-kinin system in otitis media with effusion. Publishing Authors By Initials

Y Hamaguchi,Y Majima,K Ukai,Y Sakakura,Y Miyoshi,

For similar otorhinolaryngologic diseases: ear diseases: otitis: otitis media: otitis media with effusion research abstracts see: otorhinolaryngologic diseases: ear diseases: otitis: otitis media: otitis media with effusion research

PUBMED ID PMID:

MEDLINE DATE: 1986 May-Jun

Significance of kallikrein-kinin system in otitis media with effusion. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Annals of otology, rhinology & laryngology. Su

VOLUME: 124

Page Numbers: 5-8

Journal Abbreviation:

ISSN: 0096-8056

DAY: 21

MONTH: 02

YEAR: 2008

Significance of kallikrein-kinin system in otitis media with effusion. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1256156

Significance of kallikrein-kinin system in otitis media with effusion. Keywords Mesh Terms:

KEYWORDS: Otitis Media with Effusion

MESH TERMS: metabolism

Chemical & Substance for Abstract: Significance of kallikrein-kinin system in otitis media with effusion. Information

Substance Name: Kallikreins

Registry Number: EC 3.4.21.-

Grant and Affiliation Information for Significance of kallikrein-kinin system in otitis media with effusion.

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Country: UNITED STATES

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MEDLINETA: Ann Otol Rhinol Laryngol Suppl

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