Significance of Isolated Positive IgM Serologic Results by Enzyme Immunoassay for Coccidioidomycosis.

Significance of Isolated Positive IgM Serologic Results by Enzyme Immunoassay for Coccidioidomycosis. Research Abstract Details 

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Significance of Isolated Positive IgM Serologic Results by Enzyme Immunoassay for Coccidioidomycosis. Abstract Text:

Serologic testing is important for diagnosis of coccidioidomycosis. Many methods are available for diagnostic testing. Enzyme immunoassay (EIA) can be performed quickly and locally but has the potential for false-positive results in patients manifesting a positive EIA for immunoglobulin M (IgM) antibodies and a negative EIA for immunoglobulin G (IgG). We retrospectively reviewed the charts of 405 patients with coccidioidal serologic testing performed between 1999 and 2003. Of 706 EIAs, 37 (5%) produced test results for 28 patients that showed isolated IgM positivity. Among these 28 patients, 24 (86%) had positive serologic findings by other methods (complement fixation or immunodiffusion or both), and 7 (25%) had positive microbiologic or histopathologic findings. All 4 (14%) patients without other positive serologic results had diagnostic tests with positive microbiologic or histopathologic results. No false-positive IgM assays were observed. We conclude that the false-positive rate of the EIA IgM is low, and that an isolated positive EIA IgM should prompt further follow-up and diagnostic testing.

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Significance of Isolated Positive IgM Serologic Results by Enzyme Immunoassay for Coccidioidomycosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Mycopathologia

VOLUME: 166

Page Numbers: 77-82

Journal Abbreviation: Mycopathologia

ISSN: 0301-486X

DAY: 4

MONTH: 06

YEAR: 2008

Significance of Isolated Positive IgM Serologic Results by Enzyme Immunoassay for Coccidioidomycosis. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Significance of Isolated Positive IgM Serologic Results by Enzyme Immunoassay for Coccidioidomycosis.

AFFILIATION: Division of Infectious Diseases, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ, 85259, USA.

Country: Netherlands

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MEDLINETA: Mycopathologia

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