Significance of HER-2/neu expression in ovarian epithelial tumours.

Significance of HER-2/neu expression in ovarian epithelial tumours. Research Abstract Details 

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Significance of HER-2/neu expression in ovarian epithelial tumours. Abstract Text:

Dongxia Gao,Yu Lu,Yingzhi Lu,Yuping Wang,Bo Zhang,Bingquan Wu,

OBJECTIVE: To investigate expression of Her-2/neu (c-erbB-2) and its significance in ovarian epithelial tumors. METHODS: 106 specimens and clinical history of ovarian epithelial tumors were collected including 54 cases of malignant, 33 cases of borderline and 19 benign cases. There were 19 cases of stages I and II and 35 cases of stages III and IV in ovarian carcinoma and all borderline malignant cases were stage I according to FIGO's standard. Immunohistochemical staining for Her-2/neu was performed by LSAB method. RESULTS: The positives rates of Her-2/neu of benign, borderline and malignant tumors were 47.4% (9/19), 84.8% (28/33,), and 85.2% (46/54), respectively. Both borderline and malignant cases were found to have higher expression of Her-2/neu than those of benign cases (P < 0.02 and P < 0.01) respectively. Overexpression of Her-2/neu showed in 14/54 (25.9%) of malignant cases, 3/33 (9.1%) of borderline, and none of benign cases. Overexpression of Her-2/neu in malignant tumors cases with metastasis was higher than those without metastasis (P < 0.001). CONCLUSION: Overexpression of Her-2/neu is associated with biological aggressiveness of ovarian cancer.

Significance of HER-2/neu expression in ovarian epithelial tumours. Publishing Authors By Initials

D Gao,Y Lu,Y Lu,Y Wang,B Zhang,B Wu,

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Significance of HER-2/neu expression in ovarian epithelial tumours. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua bing li xue za zhi Chinese journal of pat

VOLUME: 31

Page Numbers: 268-70

Journal Abbreviation: Zhonghua Bing Li Xue Za Zhi

ISSN: 0529-5807

DAY: 11

MONTH: Jun

YEAR: 2002

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LANGUAGE: eng

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AFFILIATION: Department of pathology, Health Science Center of Peking University, Beijing, 100083, China (Email: bqwmd@mail.bjmu.edu.cn)

Country: China

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MEDLINETA: Zhonghua Bing Li Xue Za Zhi

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