Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides.

Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides. Research Abstract Details 

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Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides. Abstract Text:

Ji Eun Lee,Takayuki Nakagawa,Tae Soo Kim,Fukuichiro Iguchi,Tsuyoshi Endo,Tomoko Kita,Norihiko Murai,Yasushi Naito,Sang Heun Lee,Juichi Ito,

Previous studies on regeneration of mammalian vestibular hair cells have indicated the potential for self-repair of damaged hair cells. The rescue of damaged hair cells from cell death may therefore increase regenerated hair cells in affected vestibular epithelia. The role of apoptosis in the degradation of vestibular hair cells following aminoglycoside treatment has been elucidated. To seek a method of protecting vestibular hair cells from aminoglycoside toxicity, we examined the apoptosis signaling pathway of vestibular hair cells due to aminoglycoside toxicity. Induction of apoptosis in hair cells of mouse ampullar cristae damaged by local application of neomycin was evaluated by the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) method and transmission electron microscopy (TEM). Immunohistochemistry for apoptosis-related proteins was employed to determine the signaling pathway of apoptosis of hair cells. The occurrence of apoptosis in hair cells was demonstrated by TUNEL staining and TEM. In apoptotic hair cells, activation of caspase-3 and -9, and redistribution of cytochrome c was identified, while there was no expression of activated caspase-8 or apoptosis-inducing factor. In conclusion, these findings indicate that the mitochondria-mediated pathway of apoptosis may play a role in inducing the apoptosis of vestibular hair cells due to aminoglycoside toxicity. Stabilization of the mitochondrial membrane may therefore rescue vestibular hair cells from apoptosis, leading to an increase in self-repaired hair cells in affected vestibular epithelia.

Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides. Publishing Authors By Initials

JE Lee,T Nakagawa,TS Kim,F Iguchi,T Endo,T Kita,N Murai,Y Naito,SH Lee,J Ito,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta oto-laryngologica. Supplementum

VOLUME:

Page Numbers: 69-74

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: Mar

YEAR: 2004

Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370355

Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides. Information

Substance Name: Caspases

Registry Number: EC 3.4.22.-

Grant and Affiliation Information for Signaling pathway for apoptosis of vestibular hair cells of mice due to aminoglycosides.

AFFILIATION: Department of Otolaryngology--Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Country: Norway

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MEDLINETA: Acta Otolaryngol Suppl

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