Signaling and regulation of the platelet glycoprotein Ib-IX-V complex.

Signaling and regulation of the platelet glycoprotein Ib-IX-V complex. Research Abstract Details 

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Signaling and regulation of the platelet glycoprotein Ib-IX-V complex. Abstract Text:

Xiaoping Du,

PURPOSE OF REVIEW: The platelet adhesion receptor, the glycoprotein Ib-IX-V complex, not only mediates platelet adhesion but also transmits signals leading to platelet activation, aggregation and secretion. Significant progress has been made recently on the signaling pathways and regulatory mechanisms involving glycoprotein Ib-IX-V function. RECENT FINDINGS: The interaction of glycoprotein Ib-IX-V with its ligand, von Willebrand factor, is dually controlled by von Willebrand factor conformation and intracellular signal-mediated regulation of glycoprotein Ib-IX-V receptor function that requires the zeta isoform of the 14-3-3 protein family (14-3-3zeta). Glycoprotein Ib-IX-V signaling is mediated by the Src family of protein kinases, phospholipase C, calcium elevation, phosphoinositol 3-kinase, and multiple amplification mechanisms including the nitric oxide-cGMP pathway, the mitogen-activated protein kinase pathway, the immunoreceptor tyrosine-based activation motif pathway, and ADP and thromboxane A2 pathways. SUMMARY: Progress in understanding the mechanism(s) regulating glycoprotein Ib-IX-V should help develop inhibitors and modifiers that interfere or augment its von Willebrand factor binding function and thus be useful for treating thrombosis and bleeding disorders. Characterization of intracellular molecules and pathways in glycoprotein Ib-IX-V signaling has implications in the development of new agents and for the use of existing drugs that affect glycoprotein Ib-IX-V signaling.

Signaling and regulation of the platelet glycoprotein Ib-IX-V complex. Publishing Authors By Initials

X Du,

For similar proteins: blood proteins: blood coagulation factors: von willebrand factor research abstracts see: proteins: blood proteins: blood coagulation factors: von willebrand factor research

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Signaling and regulation of the platelet glycoprotein Ib-IX-V complex. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in hematology

VOLUME: 14

Page Numbers: 262-9

Journal Abbreviation:

ISSN: 1065-6251

DAY: 3

MONTH: May

YEAR: 2007

Signaling and regulation of the platelet glycoprotein Ib-IX-V complex. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9430802

Signaling and regulation of the platelet glycoprotein Ib-IX-V complex. Keywords Mesh Terms:

KEYWORDS: von Willebrand Factor

MESH TERMS: metabolism

Chemical & Substance for Abstract: Signaling and regulation of the platelet glycoprotein Ib-IX-V complex. Information

Substance Name: von Willebrand Factor

Registry Number: 0

Grant and Affiliation Information for Signaling and regulation of the platelet glycoprotein Ib-IX-V complex.

AFFILIATION: Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA. xdu@uic.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL080264

ACRONYM: HL

MEDLINETA: Curr Opin Hematol

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