Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis.

Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Research Abstract Details 

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Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Abstract Text:

Dae Joon Kim,Keith S Chan,Shigetoshi Sano,John Digiovanni,

Signal transducer and activator of transcription 3 (Stat3) is one of a family of cytoplasmic proteins that participate in normal cellular responses to cytokines and growth factors as transcription factors. Stat3 modulates various physiological functions including cell survival, cell-cycle regulation, and angiogenesis through regulation of gene expression, and its constitutive activation is associated with a number of human epithelial cancers. Recent studies with skin-specific gain and loss of Stat3 function transgenic mice have shown that Stat3 plays critical roles in skin carcinogenesis. Multistage skin carcinogenesis bioassays performed with these transgenic mice clearly demonstrate that Stat3 is required for both tumor initiation and promotion through regulation of genes involved in survival and proliferation, respectively. Stat3 also plays a role in malignant progression of skin tumors by regulating genes that are involved in angiogenesis and invasion. Further studies have revealed that Stat3 plays a critical role in epidermal cell proliferation and survival following exposure to ultraviolet B (UVB) irradiation. In addition, Stat3 is constitutively active in UVB-induced skin tumors from both mice and humans. Collectively, these studies suggest that Stat3 may be a potential target for both the prevention and treatment of human epithelial cancers including skin cancer.

Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Publishing Authors By Initials

DJ Kim,KS Chan,S Sano,J Digiovanni,

For similar environment and public health: environment: meteorological factors: atmosphere: weather: sunlight: ultraviolet rays research abstracts see: environment and public health: environment: meteorological factors: atmosphere: weather: sunlight: ultraviolet rays research

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Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Journal Published:

PUBLICATION TYPE: Review

Journal: Molecular carcinogenesis

VOLUME: 46

Page Numbers: 725-31

Journal Abbreviation: Mol. Carcinog.

ISSN: 0899-1987

DAY: 3

MONTH: Aug

YEAR: 2007

Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8811105

Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Keywords Mesh Terms:

KEYWORDS: Ultraviolet Rays

MESH TERMS: metabolism

Chemical & Substance for Abstract: Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Information

Substance Name: STAT3 Transcription Factor

Registry Number: 0

Grant and Affiliation Information for Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis.

AFFILIATION: Department of Carcinogenesis, The University of Texas M.D. Anderson Cancer Center, Science Park--Research Division, Smithville, Texas 78957, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA76520

ACRONYM: CA

MEDLINETA: Mol Carcinog

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