Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction.

Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction. Research Abstract Details 

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Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction. Abstract Text:

Masatoshi Kuratsune,Takao Masaki,Takayuki Hirai,Kei Kiribayashi,Yukio Yokoyama,Tetsuji Arakawa,Noriaki Yorioka,Nobuoki Kohno,Masatoshi Kuratsune,Takao Masaki,Takayuki Hirai,Kei Kiribayashi,Yukio Yokoyama,Tetsuji Arakawa,Noriaki Yorioka,Nobuoki Kohno,

Background: In vitro studies suggest that the signal transducer and activator of transcription (STAT) plays a critical role in renal fibrosis. However, the process of STAT activation in vivo remains unclear. This study in rats aimed to localize STAT3 activation within the kidney and examine the in vivo relationship between STAT3 activation and renal fibrosis. Methods: Unilateral ureteral obstruction (UUO) was induced in the rats and the kidneys examined 3 or 7 days after obstruction. Activation of STAT3 in western blot and immunohistochemical analyses was identified by the phosphorylated form of STAT3 (pSTAT3). Results: Myofibroblasts were identified by alpha-smooth muscle actin expression and were upregulated in obstructed kidneys. pSTAT3 was localized mainly in tubular epithelial cells of collecting ducts in normal and obstructed kidneys and interstitial cells in obstructed kidneys. After UUO, western blotting showed a fourfold increase in pSTAT3, with a peak at day 7. Immunostaining showed a sixfold increase in pSTAT3 at day 7 in tubular epithelial cells and a 2500-fold increase at day 7 in interstitial cells. Conclusion: STAT3 was activated in rat tubular epithelial cells and myofibroblasts after UUO, suggesting that STAT3 may contribute to the progression of interstitial fibrosis.

Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction. Publishing Authors By Initials

M Kuratsune,T Masaki,T Hirai,K Kiribayashi,Y Yokoyama,T Arakawa,N Yorioka,N Kohno,M Kuratsune,T Masaki,T Hirai,K Kiribayashi,Y Yokoyama,T Arakawa,N Yorioka,N Kohno,

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Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nephrology (Carlton, Vic.)

VOLUME: 12

Page Numbers: 565-71

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ISSN: 1320-5358

DAY: 12

MONTH: Dec

YEAR: 2007

Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction.

AFFILIATION: Department of Molecular and Internal Medicine, Graduate School of Medical Sciences, Hiroshima University, Hiroshima City, Japan.

Country: Australia

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MEDLINETA: Nephrology (Carlton)

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