Signal amplification and detection via a supramolecular allosteric catalyst.

Signal amplification and detection via a supramolecular allosteric catalyst. Research Abstract Details 

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Signal amplification and detection via a supramolecular allosteric catalyst. Abstract Text:

Nathan C Gianneschi,SonBinh T Nguyen,Chad A Mirkin,

The design of a supramolecular allosteric catalyst system for catalytic signal amplification and detection is presented. The catalyst was switched "on" by the introduction of an analyte that also behaves as an allosteric activator. Concentrations of Cl- ions as low as 800 nM were catalytically amplified and detected. The signal was transduced via a pH-sensitive fluorescent probe and observed visually using a laboratory, handheld UV lamp and by spectrophotometry. Furthermore, the allosteric effect was quantified using gas chromatography for a range of Cl- concentrations. This three-part detection scheme involving analyte binding, allosteric catalyst activation, and signal transduction represents a new approach to small-molecule detection.

Signal amplification and detection via a supramolecular allosteric catalyst. Publishing Authors By Initials

NC Gianneschi,ST Nguyen,CA Mirkin,

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Signal amplification and detection via a supramolecular allosteric catalyst. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 1644-5

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 16

MONTH: Feb

YEAR: 2005

Signal amplification and detection via a supramolecular allosteric catalyst. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Signal amplification and detection via a supramolecular allosteric catalyst.

AFFILIATION: Department of Chemistry and the Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60201-3113, USA.

Country: United States

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MEDLINETA: J Am Chem Soc

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