Siglec-15: an immune system Siglec conserved throughout vertebrate evolution.

Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. Research Abstract Details 

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Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. Abstract Text:

Takashi Angata,Yukako Tabuchi,Kazunori Nakamura,Mitsuru Nakamura,

Siglecs are vertebrate cell-surface receptors that recognize sialylated glycans. Here we have identified and characterized a novel Siglec, named Siglec-15. Siglec-15 is a type-I transmembrane protein consisting of: (i) two immunoglobulin (Ig)-like domains, (ii) a transmembrane domain containing a lysine residue, and (iii) a short cytoplasmic tail. Siglec-15 is expressed on macrophages and/or dendritic cells of human spleen and lymph nodes. We show that the extracellular domain of Siglec-15 preferentially recognizes the Neu5Acalpha2-6GalNAcalpha- structure. Siglec-15 associates with the activating adaptor proteins DNAX activation protein (DAP)12 and DAP10 via its lysine residue in the transmembrane domain, implying that it functions as an activating signaling molecule. Siglec-15 is the second human Siglec identified to have an activating signaling potential; unlike Siglec-14, however, it does not have an inhibitory counterpart. Orthologs of Siglec-15 are present not only in mammals but also in other branches of vertebrates; in contrast, no other known Siglec expressed in the immune system has been conserved throughout vertebrate evolution. Thus, Siglec-15 probably plays a conserved, regulatory role in the immune system of vertebrates.

Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. Publishing Authors By Initials

T Angata,Y Tabuchi,K Nakamura,M Nakamura,

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Siglec-15: an immune system Siglec conserved throughout vertebrate evolution. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Glycobiology

VOLUME: 17

Page Numbers: 838-46

Journal Abbreviation: Glycobiology

ISSN: 0959-6658

DAY: 4

MONTH: 05

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan. takashi-angata@aist.go.jp

Country: England

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MEDLINETA: Glycobiology

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