[Side effects of glucocorticosteroids in the management of 1291 patients of SARS.]

[Side effects of glucocorticosteroids in the management of 1291 patients of SARS.] Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

[Side effects of glucocorticosteroids in the management of 1291 patients of SARS.] Abstract Text:

Nan Li,Guang-fa Wang,Yang-feng Wu,Gao-qiang Xie,Feng Xiao,Bo-wen Chen,Yue-xiang Wang,De-min Han,

OBJECTIVE: To analysis the relationship between glucocorticosteroids (GCS) usage and side effects in the treatment of severe acute respiratory syndrome (SARS). METHODS: All clinical records of probable SARS patients in Beijing were collected and input into an Epi6 database, in which 1 291 patients had entire information and met the clinical criteria of SARS. The usage of GCS and GCS associated side effects were analyzed retrospectively. RESULTS: Patients accepted GCS therapy were 83.96% (n=1 084), whereas 16.04%(n=207) did not take GCS. The average dosage of GCS was 160 mg/d in the first week, and then reduced to 80 mg/d and 40 mg/d in the second and the third weeks, respectively. Initial blood glucose, systolic pressure (SBP), and diastolic pressure (DBP) were no significant difference between GCS group and non-GCS group. The highest blood glucose during the treatment in GCS group was markedly higher than that in non-GCS group [(8.68+/-4.80) mmol/L vs (6.39+/-3.71) mmol/L, P<0.05)]. The highest blood glucose and average blood glucose after initiation of GCS therapy were elevated in GCS group. The levels of blood glucose were correlated with the initial, maximum, and cumulative GCS dosages. Average blood glucose was increased markedly in groups with MP(Initial) > or =80 mg/d (Methyprednisonlone), MP(Maximal) > or =160 mg/d, or MP(Cumulative) > or = 3000 mg. The blood glucose grew up significantly in the first and the second weeks in the treatment with GCS, and then returned to normal level gradually. Hyperglycemia duration in the group with MP(Cumulative) > or =3000 mg persisted longer than that in the other groups (P< 0.05). The lowest serum potassium during the treatment and the duration of hypokalemia in GCS group were significantly different from that in non-GCS group [(3.66+/-0.50) mmol/L vs (4.01+/-0.51) mmol/L, P< 0.001 ;1(1, 75) days vs 1(1, 9) days, P<0.05, respectively]. Average serum potassium and the duration of hypokalemia were related to the dosages of GCS. Serum potassium reached its nadir in the first week of GCS treatment and then grew up in the second week. In groups with MP(Initial) > or =320 mg/d, MP(Maximal) > or =320 mg/d, and MP(Cumulative) > or =3000 mg, the level of serum potassium was lower and the duration of hypokalemia was longer than that in other groups. They began to returned to normal level in the third week. Administration of GCS prolonged the time of hypocalcemia[19 (1, 74) days in GCS group vs 8 (1, 32) days in non-GCS group, P< 0.05]. The duration of hypocalcemia was prolonged according to the increasing of the maximal or the cumulative dosage of GCS. However, the duration of hypocalcemia in group with MP(Cumulative) <999 mg was similar to that in non-GCS group (P > 0.05). After GCS administration, SBP and DBP were increased gradually, and reached their peaks in the fourth week [SBP(117.2+/-14.0) mm Hg and DBP (72.5+/-9.1) mm Hg vs SBP (120.0+/-12.5) mm Hg and DBP (74.5+/-8.7) mm Hg, P< 0.05, 1 mm Hg=0.133 kPa]. CONCLUSION: Hyperglycemia and hypokalemia are correlated with GCS dosage and duration. Administration with GCS influences SBP, DBP, and duration of hypocalcemia. Appropriate low dosage of GCS (MP(Initial) and MP(Maximal) < 159 mg/d, MP(Cumulative)< 2999 mg) causes few changes of blood glucose, serum potassium, and blood calcium. It is important to monitor laboratory findings during the treatment with GCS.

[Side effects of glucocorticosteroids in the management of 1291 patients of SARS.] Publishing Authors By Initials

N Li,GF Wang,YF Wu,GQ Xie,F Xiao,BW Chen,YX Wang,DM Han,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

[Side effects of glucocorticosteroids in the management of 1291 patients of SARS.] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Beijing da xue xue bao. Yi xue ban = Journal of Pe

VOLUME: 36

Page Numbers: 519-24

Journal Abbreviation: Beijing Da Xue Xue Bao

ISSN: 1671-167X

DAY: 18

MONTH: Oct

YEAR: 2004

[Side effects of glucocorticosteroids in the management of 1291 patients of SARS.] Information

Number of References:

LANGUAGE: chi

NlmUniqueID: 101125284

[Side effects of glucocorticosteroids in the management of 1291 patients of SARS.] Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: [Side effects of glucocorticosteroids in the management of 1291 patients of SARS.] Information

Substance Name:

Registry Number:

Grant and Affiliation Information for [Side effects of glucocorticosteroids in the management of 1291 patients of SARS.]

AFFILIATION: Respiratory Department, Peking University First Hospital, Beijing 100034, China.

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Beijing Da Xue Xue Bao

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Side effects of glucocorticosteroids in the management of 1291 patients of SARS Related Publications

• An experimental study on rhBMP-2 composite bone substitute for repairing craniomaxillary bone defects.
• Cloning and expression of a novel armadillo motif containing gene in Xenopus.
• Effect of 6-OHDA lesions of the dopaminergic mesolimbic system on drug priming induced reinstatement of extinguished morphine CPP in rats.
• Schistosome transcriptomes: new insights into the parasite and schistosomiasis.
• Simple separation of chicken gonadal primordial germ cells with and without foreign genes.
• The relationship between bone-loss of steroid-induced osteonecrosis and local expression of OPG/OCIF.
• [A novel cis-acting enhancer element between CKLF and CKLFSF1 genes]
• [Application of image identification technology to the analysis system of gene chip and image processing by VB]
• [Association between angiotensin system gene polymorphism and essential hypertension]
• [Changes of platelet endothelial cell adhesion molecule-1, tissue type plasminogen activator and plasminogen activator inhibitor-1 expression in the lung tissue of neonatal rats after intraperitoneal injection with lipopolysaccharide]
• [Changes of the migration ability of the cord blood CD(34)(+) cells during short-term ex vivo expansion]
• [Characteristics of the response of vestibular evoked myogenic potentials to different stimulus modes]
• [Characterization of expression of the centrosomal protein, Cenexin, in rat spermatogenesis]
• [Compliance variation following the change of longitudinal stretch ratio. A study on femoral artery and vein in a rabbit model]
• [Construction and Identification of DNA vaccine containing chimeric gene gag-gp120 of HIV-1]
• [Correcting the congenital ala defect of the facial cleft with revolving reposition]
• [Determination of 10-HDA in honeybee body by HPLC]
• [Electroacupuncture of 2 Hz induces long-term depression of synaptic transmission in the spinal dorsal horn in rats with neuropathic pain]
• [Electroacupuncture up-regulated arcuate nucleus alpha-MSH expression in the rat of diet-induced obesity]
• [Histological observation on programmed cell death in wheat-leaf rust fungus intreaction]
• [Isolation of resisting thrombus and arteriosclerosis compounds in leaves of Salix matsudana]
• [Preliminary study on alternative half body irradiation in the treatment of hematological malignancies]
• [Preparation of standard mixture of volatile organic compounds]
• [Second allogeneic transplant for leukemia relapsed after first allogeneic transplantation]
• [Side effects of glucocorticosteroids in the management of 1291 patients of SARS.]
• [Study on drug-resistance of Mycobacterium tuberculosis isolated from coal workers with silico-tuberculosis]
• [Supplementing Qi and activating blood circulation in gene regulation of vascular smooth muscle cells]
• [The neurovascular anatomy and its clinical implication of the rectus femoris muscle]
• [The relationship between ecological immune nutrition and infection control under stress state]
• [Transferring neurovascular rectus femoris muscle segment for treatment of facial paralysis]