SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana.

SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana. Research Abstract Details 

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SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana. Abstract Text:

Michelle L Churchman,Matthew L Brown,Naohiro Kato,Viktor Kirik,Martin ,Dirk ,Lieven De Veylder,Jason D Walker,Zhengui Zheng,David G Oppenheimer,Taylor Gwin,Jason Churchman,John C Larkin,

Recessive mutations in the SIAMESE (SIM) gene of Arabidopsis thaliana result in multicellular trichomes harboring individual nuclei with a low ploidy level, a phenotype strikingly different from that of wild-type trichomes, which are single cells with a nuclear DNA content of approximately 16C to 32C. These observations suggested that SIM is required to suppress mitosis as part of the switch to endoreplication in trichomes. Here, we demonstrate that SIM encodes a nuclear-localized 14-kD protein containing a cyclin binding motif and a motif found in ICK/KRP (for Interactors of Cdc2 kinase/Kip-related protein) cell cycle inhibitor proteins. Accordingly, SIM was found to associate with D-type cyclins and CDKA;1. Homologs of SIM were detected in other dicots and in monocots but not in mammals or fungi. SIM proteins are expressed throughout the shoot apical meristem, in leaf primordia, and in the elongation zone of the root and are localized to the nucleus. Plants overexpressing SIM are slow-growing and have narrow leaves and enlarged epidermal cells with an increased DNA content resulting from additional endocycles. We hypothesize that SIM encodes a plant-specific CDK inhibitor with a key function in the mitosis-to-endoreplication transition.

SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana. Publishing Authors By Initials

ML Churchman,ML Brown,N Kato,V Kirik,M ,D ,L De Veylder,JD Walker,Z Zheng,DG Oppenheimer,T Gwin,J Churchman,JC Larkin,

For similar proteins: recombinant proteins: recombinant fusion proteins research abstracts see: proteins: recombinant proteins: recombinant fusion proteins research

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SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Plant cell

VOLUME: 18

Page Numbers: 3145-57

Journal Abbreviation: Plant Cell

ISSN: 1040-4651

DAY: 10

MONTH: 11

YEAR: 2006

SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9208688

SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana. Keywords Mesh Terms:

KEYWORDS: Recombinant Fusion Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana. Information

Substance Name: Cyclin-Dependent Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for SIAMESE, a plant-specific cell cycle regulator, controls endoreplication onset in Arabidopsis thaliana.

AFFILIATION: Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA.

Country: United States

AGENCY: United States NCRR

GRANT: P20 RR16456

ACRONYM: RR

MEDLINETA: Plant Cell

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