Sialic acids, but not their linkage to galactose residues, are required for full expression of the biological activity of human chorionic gonadotropin.

Sialic acids, but not their linkage to galactose residues, are required for full expression of the biological activity of human chorionic gonadotropin. Research Abstract Details 

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Sialic acids, but not their linkage to galactose residues, are required for full expression of the biological activity of human chorionic gonadotropin. Abstract Text:

J Amano,S Sato,R Nishimura,M Mochizuki,A Kobata,

One of the characteristic features of the asparagine-linked sugar chains of human chorionic gonadotropin (hCG) is that their sialic acid residues occur exclusively as the Neu5Ac alpha 2----3Gal group. In order to determine whether this sialic acid linkage is important for the functional role played by the sugar moiety of hCG or not, isomeric hCG containing the Neu5Ac alpha 2----6Gal group was prepared and its hormonal activity in vitro was investigated. On addition of the isomeric hCG to the culture medium of a murine Leydig tumor cell line, it was found that it shows the same hormonal activity as natural hCG.

Sialic acids, but not their linkage to galactose residues, are required for full expression of the biological activity of human chorionic gonadotropin. Publishing Authors By Initials

J Amano,S Sato,R Nishimura,M Mochizuki,A Kobata,

For similar organic chemicals: carboxylic acids: acids, acyclic: sugar acids: neuraminic acids: sialic acids research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: sugar acids: neuraminic acids: sialic acids research

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Sialic acids, but not their linkage to galactose residues, are required for full expression of the biological activity of human chorionic gonadotropin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 105

Page Numbers: 339-40

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Mar

YEAR: 1989

Sialic acids, but not their linkage to galactose residues, are required for full expression of the biological activity of human chorionic gonadotropin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Sialic acids, but not their linkage to galactose residues, are required for full expression of the biological activity of human chorionic gonadotropin. Keywords Mesh Terms:

KEYWORDS: Sialic Acids

MESH TERMS: physiology

Chemical & Substance for Abstract: Sialic acids, but not their linkage to galactose residues, are required for full expression of the biological activity of human chorionic gonadotropin. Information

Substance Name: Adenylate Cyclase

Registry Number: EC 4.6.1.1

Grant and Affiliation Information for Sialic acids, but not their linkage to galactose residues, are required for full expression of the biological activity of human chorionic gonadotropin.

AFFILIATION: Department of Biochemistry, University of Tokyo.

Country: JAPAN

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MEDLINETA: J Biochem

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