Short term triiodo-l-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats.

Short term triiodo-l-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. Research Abstract Details 

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Short term triiodo-l-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. Abstract Text:

Yue-Feng Chen,Satoru Kobayashi,Jinghai Chen,Rebecca A Redetzke,Suleman Said,Qiangrong Liang,A Martin Gerdes,Yue-Feng Chen,Satoru Kobayashi,Jinghai Chen,Rebecca A Redetzke,Suleman Said,Qiangrong Liang,A Martin Gerdes,

Thyroid hormone (TH) levels decline after a myocardial infarction (MI). Treatment with TH has been shown to improve left ventricular (LV) function in MI and other cardiovascular diseases, but the mechanisms are not clear. We have previously shown that TH can prevent myocyte apoptosis via Akt signaling in cultured neonatal rat cardiomyocytes. In this study, the effects of triiodo-l-thyronine (T3) on LV function and myocyte apoptosis after MI was examined in rats. After surgery, MI rats were treated with T3 for 3 days. Compared with sham-operated rats, MI rats showed significantly increased LV chamber dimension during systole and decreased LV function. T3 treatment increased LV +/-dP/dt but did not change LV chamber dimensions. MI rats also showed significantly increased myocyte apoptosis in the border area as assessed by DNA laddering and TUNEL assay. T3 treatment decreased the amount of DNA laddering, and reduced TUNEL positive myocytes in the border area, which was associated with phosphorylation of Akt at serine 473. These results suggest that T3 can protect myocytes against ischemia-induced apoptosis, which may be mediated by Akt signaling.

Short term triiodo-l-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. Publishing Authors By Initials

YF Chen,S Kobayashi,J Chen,RA Redetzke,S Said,Q Liang,AM Gerdes,YF Chen,S Kobayashi,J Chen,RA Redetzke,S Said,Q Liang,AM Gerdes,

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Short term triiodo-l-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of molecular and cellular cardiology

VOLUME: 44

Page Numbers: 180-7

Journal Abbreviation: J. Mol. Cell. Cardiol.

ISSN: 0022-2828

DAY: 26

MONTH: 10

YEAR: 2007

Short term triiodo-l-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. Information

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LANGUAGE: eng

NlmUniqueID: 262322

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Grant and Affiliation Information for Short term triiodo-l-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats.

AFFILIATION: Cardiovascular Research Institute, Sanford Research/University of South Dakota, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA.

Country: England

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MEDLINETA: J Mol Cell Cardiol

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