Short term outcomes of the first round of a pilot colorectal cancer screening programme with guaiac based faecal occult blood test.

Short term outcomes of the first round of a pilot colorectal cancer screening programme with guaiac based faecal occult blood test. Research Abstract Details 

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Short term outcomes of the first round of a pilot colorectal cancer screening programme with guaiac based faecal occult blood test. Abstract Text:

Bernard Denis,Marcel Ruetsch,Patrick Strentz,Jean Yves Vogel,Francis Guth,Jean Marc Boyaval,Xavier Pagnon, Ebelin,Isabelle Gendre,Philippe Perrin,

OBJECTIVE: To assess both feasibility and short term outcomes of a population based colorectal cancer screening programme using a biennial guaiac based faecal occult blood test (gFOBT). METHOD: All participants were invited by mail to take part in a screening programme using a non-rehydrated gFOBT. The gFOBTs were first provided by general practitioners (GPs) and then directly mailed to individuals who failed to comply after two invitations. The setting was a French administrative district: Haut-Rhin (710,000 inhabitants). 182,981 residents aged 50-74 years were invited to participate. RESULTS: 19,274 people (10.5%) were excluded from gFOBT screening and 90,706 completed a gFOBT, so that the participation rate was 55.4% of those eligible. 76.5% of the completed gFOBTs were provided by GPs and 15.5% by direct mailing. The gFOBT positivity rate was 3.4%. The positive predictive value was 42.7% for neoplasia (women 30.8%, men 52.5%), 23.6% for advanced adenoma, and 7.6% for cancer. The number of normal colonoscopic procedures (without neoplasia) needed to be performed for each colonoscopy detecting an advanced neoplasia was 1.8, lower in men (1.2) than in women (3.4), and decreasing with age. Detection rates for neoplasia and cancer were 12.8 and 2.3 per 1000 people screened. 206 adenocarcinomas were detected: 47.6% were stage I and 23.8% stage II. The direct cost was estimated at euro 29.3 per screened person and euro 13,466 per cancer detected. CONCLUSIONS: Participation and diagnostic yield of controlled trials of gFOBT screening are reproducible in the real world at an acceptable cost through an organised population based programme involving GPs.

Short term outcomes of the first round of a pilot colorectal cancer screening programme with guaiac based faecal occult blood test. Publishing Authors By Initials

B Denis,M Ruetsch,P Strentz,JY Vogel,F Guth,JM Boyaval,X Pagnon,JF Ebelin,I Gendre,P Perrin,

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Short term outcomes of the first round of a pilot colorectal cancer screening programme with guaiac based faecal occult blood test. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Gut

VOLUME: 56

Page Numbers: 1579-84

Journal Abbreviation: Gut

ISSN: 1458-3288

DAY: 6

MONTH: 07

YEAR: 2007

Short term outcomes of the first round of a pilot colorectal cancer screening programme with guaiac based faecal occult blood test. Information

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LANGUAGE: eng

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AFFILIATION: Médecine A, Hôpital Pasteur, 39 avenue de la Liberté, 68024, Colmar, France. bernard.denis@ch-colmar.rss.fr

Country: England

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