Short-term effects of a new bicarbonate/lactate-buffered and conventional peritoneal dialysis fluid on peritoneal and systemic inflammation in CAPD patients: a randomized controlled study.

Short-term effects of a new bicarbonate/lactate-buffered and conventional peritoneal dialysis fluid on peritoneal and systemic inflammation in CAPD patients: a randomized controlled study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Short-term effects of a new bicarbonate/lactate-buffered and conventional peritoneal dialysis fluid on peritoneal and systemic inflammation in CAPD patients: a randomized controlled study. Abstract Text:

Jernej Pajek,Radoslav Kveder,Andrej Bren,Andrej Gucek,Alojz Ihan,Josko Osredkar,Bengt Lindholm,Jernej Pajek,Radoslav Kveder,Andrej Bren,Andrej Gucek,Alojz Ihan,Josko Osredkar,Bengt Lindholm,

OBJECTIVES: This study was designed to compare the local peritoneal and systemic inflammatory effects of a conventional lactate-based (Lac) peritoneal dialysis (PD) solution and a new biocompatible bicarbonate/lactate-based (Bic/Lac) solution having low concentration of glucose degradation products. METHODS: 26 stable, prevalent PD patients were enrolled in this prospective study. They sequentially underwent 3 months of therapy with the Lac solution and 3 months with the Bic/Lac solution in a randomized order. Flow cytometry was used to measure the expression of inflammatory molecules on peritoneal cells in overnight effluent collected at the end of each study period. RESULTS: 21 patients successfully completed the study. Mean fluorescence intensity of human leukocyte antigen (HLA)-DR and CD14 expression by macrophages were not different between Lac and Bic/Lac. The peritoneal appearance rate of cancer antigen 125 (kU/minute) was 68 +/- 37 with Lac and 133 +/- 66 with Bic/Lac (p < 0.001), and of interleukin (IL)-6 (ng/minute), 0.28 +/- 0.2 with Lac and 0.18 +/- 0.16 with Bic/Lac (p = 0.014). HLA-DR macrophage expression and IL-6 peritoneal appearance rates did not correlate. Serum concentrations with Lac and Bic/Lac were, for IL-6, 3.49 +/- 2.28 and 3.72 +/- 2.46 ng/L (p = 0.17), and for high-sensitivity C-reactive protein, 2.31 +/- 2.98 and 2.71 +/- 3.31 mg/L (p = 0.32) respectively. The concentration of effluent macrophages (x10(6)/L) with Lac was 1.6 +/- 1.6 and with Bic/Lac 2.6 +/- 3.3 (p = 0.07). CONCLUSIONS: We conclude that, although there was a significant reduction in peritoneal IL-6 in patients using Bic/Lac solution, systemic levels of inflammatory markers did not differ between the two solutions and no changes were present in macrophage surface activation markers, suggesting perhaps a less important role of peritoneal macrophages in the intraperitoneal chronic inflammatory process. The number of effluent macrophages tended to be higher in patients using the Bic/Lac solution, possibly contributing to improved intraperitoneal defense.

Short-term effects of a new bicarbonate/lactate-buffered and conventional peritoneal dialysis fluid on peritoneal and systemic inflammation in CAPD patients: a randomized controlled study. Publishing Authors By Initials

J Pajek,R Kveder,A Bren,A Gucek,A Ihan,J Osredkar,B Lindholm,J Pajek,R Kveder,A Bren,A Gucek,A Ihan,J Osredkar,B Lindholm,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE: 2008 Jan-Feb

Short-term effects of a new bicarbonate/lactate-buffered and conventional peritoneal dialysis fluid on peritoneal and systemic inflammation in CAPD patients: a randomized controlled study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Peritoneal dialysis international : journal of the

VOLUME: 28

Page Numbers: 44-52

Journal Abbreviation:

ISSN: 0896-8608

DAY: 7

MONTH: 01

YEAR: 2008

Short-term effects of a new bicarbonate/lactate-buffered and conventional peritoneal dialysis fluid on peritoneal and systemic inflammation in CAPD patients: a randomized controlled study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8904033

Short-term effects of a new bicarbonate/lactate-buffered and conventional peritoneal dialysis fluid on peritoneal and systemic inflammation in CAPD patients: a randomized controlled study. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Short-term effects of a new bicarbonate/lactate-buffered and conventional peritoneal dialysis fluid on peritoneal and systemic inflammation in CAPD patients: a randomized controlled study. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Short-term effects of a new bicarbonate/lactate-buffered and conventional peritoneal dialysis fluid on peritoneal and systemic inflammation in CAPD patients: a randomized controlled study.

AFFILIATION: Department of Nephrology, University Medical Center Ljubljana;

Country: Canada

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Perit Dial Int

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Short-term effects of a new bicarbonate/lactate-buffered and conventional peritoneal dialysis fluid on peritoneal and systemic inflammation in CAPD patients: a randomized controlled study Related Publications

• A century of pituitary surgery: Schloffer's legacy.
• A combination of a PPAR-gamma agonist and an angiotensin II receptor blocker attenuates proinflammatory signaling and stimulates expression of Smad7 in human peritoneal mesothelial cells.
• Accuracy of plasma turbidity measurement for determining fat intolerance during total parenteral nutrition.
• Appetite disorders in uremia.
• Biochemical studies of tibial fracture callus in growing osteopenic rats.
• Biochemical studies on femoral cortical bone in growing osteopenic rats.
• Bone resorption and remodelling. Morphologic, biochemical and metabolic studies in the growing osteopathic rat.
• Congenital malformations: an evaluation of various types and etiologic factors in 64 cases.
• Endoscopy of the tracheobronchial tree by flexible fibreoptics and television.
• Histological components of femoral bone in growing osteopenic rats.
• Histological components of tibial fracture callus in growing osteopenic rats.
• How accurate is the description of transport kinetics in peritoneal dialysis according to different versions of the three-pore model?
• Immunotherapy of tumors with monoclonal antibodies.
• Localised disuse osteoporosis. Experimental studies in the adult rat.
• Nuclear localized protein-1 (Nulp1) increases cell death of human osteosarcoma cells and binds the X-linked inhibitor of apoptosis protein.
• Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality.
• Perilipin and adipophilin expression in lipid loaded macrophages.
• Plasma lipid metabolism at trauma: appearance of characteristic apolipoproteins in high density lipoproteins.
• Poor Outcomes for Fast Transporters on PD: The Rise and Fall of a Clinical Concern.
• Postoperative geriatric rehabilitation.
• Short-term effects of a new bicarbonate/lactate-buffered and conventional peritoneal dialysis fluid on peritoneal and systemic inflammation in CAPD patients: a randomized controlled study.
• Studies of the skeletal mass and bone formation of tibial fracture callus and femoral bone in growing osteopenic rats.
• Studies on some parameters of adrenocortical function.
• Subcutaneous rupture of the Achilles tendon; a study of 92 cases.
• Subtalar arthrodesis in poliomyelitis. A clinical study on triple arthrodesis with and without simultaneous tendon transfer in 211 adult feet, including some cases of Lambrinudi's arthrodesis for drop-foot.
• The effect of remobilisation on the extremity of the adult rat after short-term immobilisation in a plaster cast.
• The role of transforming growth factor-beta on retarded osteoblastic differentiation in vitro.
• Tissue therapy in osteoarthrosis.
• Ultrafiltration and absorption in evaluating aquaporin function from peritoneal transport of sodium.
• X-linked inhibitor of apoptosis protein increases mitochondrial antioxidants through NF-kappaB activation.