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Short photoperiod and testosterone-induced modification of GnRH release from the hypothalamus of Peromyscus maniculatus.

Short photoperiod and testosterone-induced modification of GnRH release from the hypothalamus of Peromyscus maniculatus. Research Abstract Details 

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  • Short photoperiod and testosterone-induced modification of GnRH release from the hypothalamus of Peromyscus maniculatus. Abstract Text:

    eric m mintzEric M Mintz,kim r lavenburgKim R Lavenburg,james l blankJames L Blank,eric m mintzEric M Mintz,kim r lavenburgKim R Lavenburg,james l blankJames L Blank,eric m mintzEric M Mintz,kim r lavenburgKim R Lavenburg,james l blankJames L Blank,

    Seasonally breeding animals undergo numerous physiological changes in response to changes in the length of the photoperiod. In most warm-weather breeding rodents, these changes result in reproductive quiescence during short photoperiods. It has been hypothesized that this change is mediated by changes in the activity of gonadotropin-releasing (GnRH) hormone neurons of the hypothalamus. This study was designed to test whether there are changes in the releasable pool of GnRH in the hypothalamus in response to changes in photoperiod, the presence of gonadal steroids, or the responsiveness of the individual animal to photoperiodic changes. Male deer mice (Peromyscus maniculatus) were maintained on long or short day photoperiod and either left intact, castrated, or castrated with testosterone replacement. KCl-evoked GnRH release was measured from hypothalamic explants from each animal and compared between long and short days, between castrated, intact, and castrated with testosterone replacement animals, and between animals that did or did not show gonadal regression in response to short day treatment. There was a significant decline in evoked release of GnRH in short day housed animals when comparing photoperiod responsive mice to nonresponsive mice. In addition, both reproductively nonresponsive and long day-housed mice release less GnRH following castration than their intact counterparts. When castrated long day-housed mice were provided with long day levels of testosterone, evoked GnRH release was restored to intact levels. Taken together, the results of this study suggest that variation in testicular response to short days is most likely due to differences in the release of GnRH from the hypothalamus.

    Short photoperiod and testosterone-induced modification of GnRH release from the hypothalamus of Peromyscus maniculatus. Publishing Authors By Initials

    em mintzEM Mintz,kr lavenburgKR Lavenburg,jl blankJL Blank,em mintzEM Mintz,kr lavenburgKR Lavenburg,jl blankJL Blank,em mintzEM Mintz,kr lavenburgKR Lavenburg,jl blankJL Blank,

    For similar abstracts research abstracts see: abstracts research

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    Short photoperiod and testosterone-induced modification of GnRH release from the hypothalamus of Peromyscus maniculatus. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Brain research

    VOLUME: 1180

    Page Numbers: 20-8

    Journal Abbreviation: Brain Res.

    ISSN: 0006-8993

    DAY: 16

    MONTH: 09

    YEAR: 2007

    Short photoperiod and testosterone-induced modification of GnRH release from the hypothalamus of Peromyscus maniculatus. Information

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    LANGUAGE: eng

    NlmUniqueID: 45503

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    Grant and Affiliation Information for Short photoperiod and testosterone-induced modification of GnRH release from the hypothalamus of Peromyscus maniculatus.

    AFFILIATION: Department of Biological Sciences, Kent State University, Kent, OH 44242, USA. emintz@kent.edu

    Country: Netherlands

    Netherlands Research PublicationNetherlands Research Publication

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    MEDLINETA: Brain Res

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