Short perioperative versus long-term adjuvant chemotherapy.

Short perioperative versus long-term adjuvant chemotherapy. Research Abstract Details 

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Short perioperative versus long-term adjuvant chemotherapy. Abstract Text:

R Nissen-Meyer,H Host,K Kjellgren,B Mansson,T Norin,

A single course of cyclophosphamide IV 5 mg/kg daily for 6 days was given immediately after mastectomy to 507 patients (519 randomized controls). The relapse-free rates were significantly increased, and after 16 years the difference was 12%. In a parallel series the same adjuvant course was given 2-4 weeks after mastectomy to 52 patients (58 randomized controls). No effect of this delayed course was found. In a second study a short multidrug course was given to all patients immediately after mastectomy. One-half of the axillary node-positive cases were randomized to continue with IV CMF for 1 year. The preliminary observations show that the prolonged treatment improved the relapse-free rates significantly during the first few years. One year after mastectomy the difference was 10%; after 2 years, 9%; after 3 years, 11%; and after 4 years, 9%. The side-effects of the short course were negligible, but the side-effects of prolonged treatment were considerable and increased with increasing treatment duration. More trials are needed to find the optimum duration of adjuvant chemotherapy.

Short perioperative versus long-term adjuvant chemotherapy. Publishing Authors By Initials

R Nissen-Meyer,H Host,K Kjellgren,B Mansson,T Norin,

For similar investigative techniques: epidemiologic methods: epidemiologic research design: random allocation research abstracts see: investigative techniques: epidemiologic methods: epidemiologic research design: random allocation research

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MEDLINE DATE:

Short perioperative versus long-term adjuvant chemotherapy. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 98

Page Numbers: 91-8

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 1985

Short perioperative versus long-term adjuvant chemotherapy. Information

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LANGUAGE: eng

NlmUniqueID: 44671

Short perioperative versus long-term adjuvant chemotherapy. Keywords Mesh Terms:

KEYWORDS: Random Allocation

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Short perioperative versus long-term adjuvant chemotherapy. Information

Substance Name: Cyclophosphamide

Registry Number: 50-18-0

Grant and Affiliation Information for Short perioperative versus long-term adjuvant chemotherapy.

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Country: GERMANY, WEST

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MEDLINETA: Recent Results Cancer Res

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