Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis.

Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis. Research Abstract Details 

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Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis. Abstract Text:

Gary Fanjiang,George H Russell,Aubrey J Katz,

OBJECTIVES: We evaluated the response to infliximab in pediatric patients with ulcerative colitis (UC) and their long-term follow-up. We expanded our previous study of 14 patients and furthermore evaluated the success of weaning patients from infliximab. PATIENTS AND METHODS: We reviewed the charts of 27 pediatric patients with UC who were treated with infliximab instead of undergoing a colectomy. Patients with new-onset UC refractory to intravenous steroids for 5 to 10 days and patients with non-steroid-dependent UC with an acute exacerbation were classified as acutely ill (n = 16); patients with chronic steroid-dependent UC were classified as chronically ill (n = 11). The Lichtiger Colitis Activity Index (LCAI) was measured for all patients at baseline and at 1 and 2 months after treatment with infliximab was initiated. Patients were regarded as successfully treated if they remained off steroids and avoided colectomy. RESULTS: The acutely ill group had a mean LCAI score of 11.4 at induction and 0.3 after 2 months. The chronically ill group had a mean LCAI score of 11.2 at induction and 5.5 after 2 months. Treatment with infliximab was successful in 75% of acutely ill patients and in 27% of chronically ill patients. Infliximab was discontinued in 80% of successfully treated patients (83% of acutely ill, 67% of chronically ill). These patients had an average of 10 infusions and a mean follow-up time of 10 months from their last infliximab infusion. CONCLUSIONS: Our results suggest that infliximab is more effective in acutely ill UC patients than in patients with chronic steroid-dependent UC. In addition, some patients treated with infliximab can be weaned from infliximab and maintain remission.

Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis. Publishing Authors By Initials

G Fanjiang,GH Russell,AJ Katz,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of pediatric gastroenterology and nutritio

VOLUME: 44

Page Numbers: 312-7

Journal Abbreviation: J. Pediatr. Gastroenterol. Nut

ISSN: 1536-4801

DAY: 3

MONTH: Mar

YEAR: 2007

Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8211545

Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis. Information

Substance Name: infliximab

Registry Number: 0

Grant and Affiliation Information for Short- and long-term response to and weaning from infliximab therapy in pediatric ulcerative colitis.

AFFILIATION: Department of Pediatric Gastroenterology & Nutrition, Massachusetts General Hospital for Children, Boston 02114, USA. gfanjiang@partners.org

Country: United States

AGENCY: United States AHRQ

GRANT: T32-HS00060

ACRONYM: HS

MEDLINETA: J Pediatr Gastroenterol Nutr

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