Shigella applies molecular mimicry to subvert vinculin and invade host cells.

Shigella applies molecular mimicry to subvert vinculin and invade host cells. Research Abstract Details 

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Shigella applies molecular mimicry to subvert vinculin and invade host cells. Abstract Text:

Tina Izard,Guy Tran Van Nhieu,Philippe R J Bois,

Shigella flexneri, the causative agent of bacillary dysentery, injects invasin proteins through a type III secretion apparatus upon contacting the host cell, which triggers pathogen internalization. The invasin IpaA is essential for S. flexneri pathogenesis and binds to the cytoskeletal protein vinculin to facilitate host cell entry. We report that IpaA harbors two vinculin-binding sites (VBSs) within its C-terminal domain that bind to and activate vinculin in a mutually exclusive fashion. Only the highest affinity C-terminal IpaA VBS is necessary for efficient entry and cell-cell spread of S. flexneri, whereas the lower affinity VBS appears to contribute to vinculin recruitment at entry foci of the pathogen. Finally, the crystal structures of vinculin in complex with the VBSs of IpaA reveal the mechanism by which IpaA subverts vinculin's functions, where S. flexneri utilizes a remarkable level of molecular mimicry of the talin-vinculin interaction to activate vinculin. Mimicry of vinculin's interactions may therefore be a general mechanism applied by pathogens to infect the host cell.

Shigella applies molecular mimicry to subvert vinculin and invade host cells. Publishing Authors By Initials

T Izard,G Tran Van Nhieu,PR Bois,

For similar proteins: cytoskeletal proteins: vinculin research abstracts see: proteins: cytoskeletal proteins: vinculin research

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Shigella applies molecular mimicry to subvert vinculin and invade host cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of cell biology

VOLUME: 175

Page Numbers: 465-75

Journal Abbreviation: J. Cell Biol.

ISSN: 0021-9525

DAY: 6

MONTH: Nov

YEAR: 2006

Shigella applies molecular mimicry to subvert vinculin and invade host cells. Information

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LANGUAGE: eng

NlmUniqueID: 375356

Shigella applies molecular mimicry to subvert vinculin and invade host cells. Keywords Mesh Terms:

KEYWORDS: Vinculin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Shigella applies molecular mimicry to subvert vinculin and invade host cells. Information

Substance Name: Vinculin

Registry Number: 125361-02-6

Grant and Affiliation Information for Shigella applies molecular mimicry to subvert vinculin and invade host cells.

AFFILIATION: Cell Adhesion Laboratory, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. tina.izard@stjude.org

Country: United States

AGENCY: United States NIGMS

GRANT: GM071596

ACRONYM: GM

MEDLINETA: J Cell Biol

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