Shift in Induction Mechanisms Underlies an Age-Dependent Increase in DHPG-Induced Synaptic Depression at CA3 CA1 Synapses.

Shift in Induction Mechanisms Underlies an Age-Dependent Increase in DHPG-Induced Synaptic Depression at CA3 CA1 Synapses. Research Abstract Details 

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Shift in Induction Mechanisms Underlies an Age-Dependent Increase in DHPG-Induced Synaptic Depression at CA3 CA1 Synapses. Abstract Text:

Ashok Kumar,Thomas C Foster,Ashok Kumar,Thomas C Foster,

Several forms of log-term synaptic plasticity have been identified and the mechanisms for induction and expression of synaptic modifications change over development and maturation. The present study examines age-related changes in the induction of group I metabotropic receptor selective agonist (R,S)-3,5-dihydroxyphenylglycine (DHPG) induced long-term synaptic depression (DHPG-LTD) at CA3-CA1 synapses. The results demonstrate that the magnitude of DHPG-LTD is enhanced in male aged Fischer 344 rats compared with young adults. The role of mGluR1 in the induction of DHPG-LTD was increased with advanced age and, in contrast to young adults, induction involved a significant contribution of NMDA receptors and L-type Ca(2+) channels. Moreover, the protein tyrosine phosphatase inhibitor sodium orthovanadate significantly attenuated DHPG-LTD only in young adults. The expression of DHPG-LTD in aged animals was dependent on protein synthesis and the enhanced expression was associated with an increase in paired-pulse facilitation. The results provide evidence that DHPG-LTD is one of the few forms of synaptic plasticity that increases with advanced age and suggest that DHPG-LTD may contribute to age-related changes in hippocampal function.

Shift in Induction Mechanisms Underlies an Age-Dependent Increase in DHPG-Induced Synaptic Depression at CA3 CA1 Synapses. Publishing Authors By Initials

A Kumar,TC Foster,A Kumar,TC Foster,

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Shift in Induction Mechanisms Underlies an Age-Dependent Increase in DHPG-Induced Synaptic Depression at CA3 CA1 Synapses. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of neurophysiology

VOLUME: 98

Page Numbers: 2729-36

Journal Abbreviation: J. Neurophysiol.

ISSN: 0022-3077

DAY: 26

MONTH: 09

YEAR: 2007

Shift in Induction Mechanisms Underlies an Age-Dependent Increase in DHPG-Induced Synaptic Depression at CA3 CA1 Synapses. Information

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LANGUAGE: eng

NlmUniqueID: 375404

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Grant and Affiliation Information for Shift in Induction Mechanisms Underlies an Age-Dependent Increase in DHPG-Induced Synaptic Depression at CA3 CA1 Synapses.

AFFILIATION: Department of Neuroscience, McKnight Brain Institute, University of Florida, PO Box 100244, Gainesville, FL 32610-0244. foster@mbi.ufl.edu).

Country: United States

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MEDLINETA: J Neurophysiol

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