Shengmai-san Enhances Antioxidant Potential in C2C12 Myoblasts Through the Induction of Intracellular Glutathione Peroxidase.

Shengmai-san Enhances Antioxidant Potential in C2C12 Myoblasts Through the Induction of Intracellular Glutathione Peroxidase. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Shengmai-san Enhances Antioxidant Potential in C2C12 Myoblasts Through the Induction of Intracellular Glutathione Peroxidase. Abstract Text:

Hiroshi Nishida,Haruyo Ichikawa,Tetsuya Konishi,Hiroshi Nishida,Haruyo Ichikawa,Tetsuya Konishi,

Cellular and tissue injury associated with reactive oxygen species (ROS) has been reported in many kinds of disorders. While the antioxidant enzymes play critical roles in inhibiting the ROS-mediated injury, glutathione peroxidase (GPx) is scavenging hydroperoxides including H(2)O(2). We previously reported that Shengmai-san (SMS), a traditional Chinese medicine, prevented ischemia/reperfusion injury of the brain and other organs in rats. To clarify the effect of SMS on intracellular responses of muscle cells against oxidative stress, C2C12 myoblasts were subjected to H(2)O(2) abuse. SMS pre-incubation prevented the decreasing cell viability after H(2)O(2) treatment. The accumulations of cellular protein carbonyl associated with apoptotic cell death were also inhibited by the SMS pre-incubation prior to oxidative damage induction. At the same time, enhanced activity, protein, and mRNA expression levels of GPx were observed in cells pre-incubated with SMS prior to H(2)O(2) abuse. Moreover, intracellular GSH was subsequently decreased after H(2)O(2) treatment. These findings suggest that SMS improved the antioxidant capacity against acute oxidative stress through the constitutive enhancement of GPx expression in C2C12 myoblasts. Because of its antioxidative property, SMS might be useful not only for the oxidative damage associated diseases but also for the transplantation of myoblasts into muscular dystrophy patients.

Shengmai-san Enhances Antioxidant Potential in C2C12 Myoblasts Through the Induction of Intracellular Glutathione Peroxidase. Publishing Authors By Initials

H Nishida,H Ichikawa,T Konishi,H Nishida,H Ichikawa,T Konishi,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Shengmai-san Enhances Antioxidant Potential in C2C12 Myoblasts Through the Induction of Intracellular Glutathione Peroxidase. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pharmacological sciences

VOLUME: 105

Page Numbers: 342-52

Journal Abbreviation: J. Pharmacol. Sci.

ISSN: 1347-8613

DAY: 1

MONTH: 12

YEAR: 2007

Shengmai-san Enhances Antioxidant Potential in C2C12 Myoblasts Through the Induction of Intracellular Glutathione Peroxidase. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101167001

Shengmai-san Enhances Antioxidant Potential in C2C12 Myoblasts Through the Induction of Intracellular Glutathione Peroxidase. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Shengmai-san Enhances Antioxidant Potential in C2C12 Myoblasts Through the Induction of Intracellular Glutathione Peroxidase. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Shengmai-san Enhances Antioxidant Potential in C2C12 Myoblasts Through the Induction of Intracellular Glutathione Peroxidase.

AFFILIATION: Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Pharmacol Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Shengmai-san Enhances Antioxidant Potential in C2C12 Myoblasts Through the Induction of Intracellular Glutathione Peroxidase Related Publications

• Amino acid sequence of alpha chain of sarcoplasmic calcium binding protein obtained from shrimp tail muscle.
• Amino acid sequence of horseshoe crab, Tachypleus tridentatus, striated muscle troponin C.
• Amino acid sequence of the beta chain of sarcoplasmic calcium binding protein (SCP) obtained from shrimp tail muscle.
• Amino acid sequence of troponin C obtained from ascidian (Halocynthia roretzi) body wall muscle.
• CHROMATOGRAPHY OF NUCLEIC ACIDS COMPONENTS.
• Co-immunization with West Nile DNA and inactivated vaccines provides synergistic increases in their immunogenicities in mice.
• DCCD-sensitive Na+-transport in the membrane vesicles of Halobacterium halobium.
• DCCD-sensitive, Na+-dependent H+-influx process coupled to membrane potential formation in membrane vesicles of Halobacterium halobium.
• DNA hypermethylation status of multiple genes in papillary thyroid carcinomas.
• Deletion and purification studies to elucidate the structure of the Actinobacillus actinomycetemcomitans cytolethal distending toxin.
• Emergence of multiplicative auditory responses in the midbrain of the barn owl.
• First results from the crystal structure analysis beamline at SPring-8.
• Gamma loop dysfunction of the quadriceps femoris of elderly patients hospitalized after fall injury.
• High-speed gel filtration of polypeptides in sodium dodecyl sulfate.
• In Vitro and in Vivo Anti-oxidant Activity of Hot Water Extract of Basidiomycetes-X, Newly Identified Edible Fungus.
• Infection-enhancing and -neutralizing activities of mouse monoclonal antibodies against dengue type 2 and 4 viruses are controlled by complement levels.
• Mechanism of adenosine triphosphate-dependent Ca2+ uptake of brain microsomes.
• Molecular weights of acetylcholine receptor subunits from Narke japonica.
• MyD88 but Not TLR2, 4 or 9 Is Essential for IL-12 Induction by Lactic Acid Bacteria.
• Physico-chemical properties of acetylcholine receptor proteins from Narke japonica.
• Prostate cancer antigen-1 contributes to cell survival and invasion though discoidin receptor 1 in human prostate cancer.
• Psychological Stress-Induced Oxidative Stress as a Model of Sub-Healthy Condition and the Effect of TCM.
• Removal of troponin C and desensitization of myosin B from ascidian smooth muscle by treatment with ethylene diamine tetraacetate.
• Separation of low molecular weight RNA species by high-speed gel filtration.
• Shengmai-san Enhances Antioxidant Potential in C2C12 Myoblasts Through the Induction of Intracellular Glutathione Peroxidase.
• The Zebrafish fgf Family.
• The dihydro-beta-agarofuran sesquiterpenoids.
• The effects of storage of sarcoplasmic reticulum fragments on the Ca2+, Mg2+-ATPase.
• [Idiopathic sustained ventricular tachycardia]
• c-Jun NH2 terminal kinase activation and decreased expression of mitogen-activated protein kinase phosphatase-1 play important roles in invasion and angiogenesis of urothelial carcinomas.