In a set of 190 duplicate gene pairs in yeast Saccharomyces cerevisiae, the sharing of transcription factors tended to decrease with increased divergence in coding sequence, at both synonymous and nonsynonymous sites. Our results showed a significantly higher sharing of transcription factors by duplicated gene pairs falling within duplicated genomic blocks than in other duplicated gene pairs; and genes in duplicated blocks also showed significantly greater conservation at the coding sequence level. In spite of the overall trends, there were certain gene pairs, both in duplicated blocks and in other genomic regions, which were highly divergent in coding sequence and yet had identical patterns of transcription factor binding. These results suggest that functional differentiation of genes after duplication is a multi-dimensional process, with different duplicate pairs differentiating in different ways.
Sharing of transcription factors after gene duplication in the yeast Saccharomyces cerevisiae. Publishing Authors By Initials
Sharing of transcription factors after gene duplication in the yeast Saccharomyces cerevisiae. Journal Published:
PUBLICATION TYPE: Research Support, N.I.H., Extr
Journal: Genetica
VOLUME: 129
Page Numbers: 301-8
Journal Abbreviation: Genetica
ISSN: 0016-6707
DAY: 4
MONTH: 08
YEAR: 2006
Sharing of transcription factors after gene duplication in the yeast Saccharomyces cerevisiae. Information
Number of References:
LANGUAGE: eng
NlmUniqueID: 370740
Sharing of transcription factors after gene duplication in the yeast Saccharomyces cerevisiae. Keywords Mesh Terms:
KEYWORDS: Variation (Genetics)
MESH TERMS: genetics
Chemical & Substance for Abstract: Sharing of transcription factors after gene duplication in the yeast Saccharomyces cerevisiae. Information
Substance Name: Transcription Factors
Registry Number: 0
Grant and Affiliation Information for Sharing of transcription factors after gene duplication in the yeast Saccharomyces cerevisiae.
AFFILIATION: Department of Biological Sciences, University of South Carolina, Coker Life Sciences Bldg. 700 Sumter St., Columbia, SC 29208, USA. austin@biol.sc.edu
Country: Netherlands
AGENCY: United States NIGMS
GRANT: GM43940
ACRONYM: GM
MEDLINETA: Genetica
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