Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display.

Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display. Abstract Text:

Rolf K Swoboda,Rajasekharan Somasundaram,Laura Caputo,Elizabeth M Ochoa,Phyllis A Gimotty,Francesco M Marincola,Patricia Van Belle,Stephen Barth,David Elder,DuPont Guerry,Brian Czerniecki,Lynn Schuchter,Robert H Vonderheide,Dorothee Herlyn,

Antigens recognized by T helper (Th) cells in the context of MHC class II molecules have vaccine potential against cancer and infectious agents. We have described previously a melanoma patient's HLA-DR7-restricted Th cell clone recognizing an antigen, which is shared among melanoma and glioma cells derived from various patients. Here, this antigen was cloned using a novel antigen phage display approach. The antigen was identified as the ribosomal protein L8 (RPL8). A peptide of RPL8 significantly stimulated proliferation and/or cytokine expression of the Th cell clone and lymphocytes in four of nine HLA-DR7(+) melanoma patients but not in healthy volunteers. The RPL8 antigen may represent a relevant vaccine target for patients with melanoma, glioma, and breast carcinoma whose tumors express this protein.

Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display. Publishing Authors By Initials

RK Swoboda,R Somasundaram,L Caputo,EM Ochoa,PA Gimotty,FM Marincola,P Van Belle,S Barth,D Elder,D Guerry,B Czerniecki,L Schuchter,RH Vonderheide,D Herlyn,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, helper-inducer research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, helper-inducer research

PUBMED ID PMID:

MEDLINE DATE:

Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 67

Page Numbers: 3555-9

Journal Abbreviation:

ISSN: 0008-5472

DAY: 15

MONTH: Apr

YEAR: 2007

Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes, Helper-Inducer

MESH TERMS: immunology

Chemical & Substance for Abstract: Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display. Information

Substance Name: ribosomal protein L8

Registry Number: 0

Grant and Affiliation Information for Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display.

AFFILIATION: Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA 88193

ACRONYM: CA

MEDLINETA: Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display Related Publications

• Adenovirus infection enhances killing of melanoma cells by a mitotoxin.
• An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.
• CCN3 controls 3D spatial localization of melanocytes in the human skin through DDR1.
• Downregulation of CCN3 expression as a potential mechanism for melanoma progression.
• Dynamics of cell interactions and communications during melanoma development.
• Endothelial cells as targets for tumor therapy.
• Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels.
• Learning the ABCs of Melanoma-Initiating Cells.
• Life isn't flat: taking cancer biology to the next dimension.
• Melanoma and the tumor microenvironment.
• Melanoma stem cells: the dark seed of melanoma.
• Old disease, new culprit: tumor stem cells in cancer.
• Peptides mimicking GD2 ganglioside elicit cellular, humoral and tumor-protective immune responses in mice.
• Salmonella typhimurium as a novel RNA interference vector for cancer gene therapy.
• Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display.
• Targeting the stromal fibroblasts: a novel approach to melanoma therapy.
• The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis.
• The many faces of Notch signaling in skin-derived cells.
• Unraveling the mysteries of IGF-1 signaling in melanoma.
• [1st successful immunization of pancreas and colorectal carcinoma patients with CO17-1A-vaccine]
• [Not Available.]
• [POSTOPERATIVE EFFECTS OF CESAREAN SECTION.]
• [Stability of Teschen, HCC, ND and vaccinia viruses against 5 disinfectants]