Shared epigenetic mechanisms control virulence factors in protozoan parasites.

Shared epigenetic mechanisms control virulence factors in protozoan parasites. Research Abstract Details 

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Shared epigenetic mechanisms control virulence factors in protozoan parasites. Abstract Text:

Jose Juan Lopez-Rubio, Riviere,Artur Scherf,Jose Juan Lopez-Rubio, Riviere,Artur Scherf,Jose Juan Lopez-Rubio, Riviere,Artur Scherf,

Protozoan pathogens have evolved countermeasures to avoid immune clearance and prolong the period of infection in their vertebrate hosts. The type and degree of immune escape strategies depends on the in vivo 'lifestyle' the pathogen has adopted. Here we describe how parasites use different strategies to coordinate their expression of phenotypic variation, which is used in many cases to fool the immune system, or to successfully invade new host cells. Recent insights using modern molecular biology techniques show that this is achieved via a coordinated manner of action of different epigenetic factors such as histone marks, subnuclear localization, or novel unknown mechanism(s). This emerging field may have an enormous impact on disease therapy.

Shared epigenetic mechanisms control virulence factors in protozoan parasites. Publishing Authors By Initials

JJ Lopez-Rubio,L Riviere,A Scherf,JJ Lopez-Rubio,L Riviere,A Scherf,JJ Lopez-Rubio,L Riviere,A Scherf,

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Shared epigenetic mechanisms control virulence factors in protozoan parasites. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Current opinion in microbiology

VOLUME: 10

Page Numbers: 560-8

Journal Abbreviation: Curr. Opin. Microbiol.

ISSN: 1369-5274

DAY: 19

MONTH: 11

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9815056

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Grant and Affiliation Information for Shared epigenetic mechanisms control virulence factors in protozoan parasites.

AFFILIATION: Unité de Biologie des Interactions Hôte-Parasite, CNRS-URA 2581, Institut Pasteur, Paris, France.

Country: England

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MEDLINETA: Curr Opin Microbiol

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