Sexual dimorphism in liver mitochondrial oxidative capacity is conserved under caloric restriction conditions.

Sexual dimorphism in liver mitochondrial oxidative capacity is conserved under caloric restriction conditions. Research Abstract Details 

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Sexual dimorphism in liver mitochondrial oxidative capacity is conserved under caloric restriction conditions. Abstract Text:

A Valle,R Guevara,F J ,P Roca,J Oliver,A Valle,R Guevara,F J ,P Roca,J Oliver,A Valle,R Guevara,F J ,P Roca,J Oliver,

Caloric restriction (CR) without malnutrition has been shown to increase maximal life span and delay the rate of aging in a wide range of species. It has been proposed that reduction in energy expenditure and oxidative damage may explain the life-extending effect of CR. Sex-related differences also have been shown to influence longevity and energy expenditure in many mammalian species. The aim of the present study was to determine the sex-related differences in rat liver mitochondrial machinery, bioenergetics, and oxidative balance in response to short-term CR. Mitochondria were isolated from 6-mo-old male and female Wistar rats fed ad libitum or subjected to 40% CR for 3 mo. Mitochondrial O(2) consumption, activities of the oxidative phosphorylation system (complexes I, III, IV, and V), antioxidative activities [MnSOD, glutathione peroxidase (GPx)], mitochondrial DNA and protein content, mitochondrial H(2)O(2) production, and markers of oxidative damage, as well as cytochrome C oxidase and mitochondrial transcription factor A levels, were measured. Female rats showed a higher oxidative capacity and GPx activity than males. This sexual dimorphism was not modified by CR. Restricted rats showed slightly increased oxygen consumption, complex III activity, and GPx antioxidant activity together with lower levels of oxidative damage. In conclusion, the sexual dimorphism in liver mitochondrial oxidative capacity was unaffected by CR, with females showing higher mitochondrial functionality and ROS protection than males.

Sexual dimorphism in liver mitochondrial oxidative capacity is conserved under caloric restriction conditions. Publishing Authors By Initials

A Valle,R Guevara,FJ ,P Roca,J Oliver,A Valle,R Guevara,FJ ,P Roca,J Oliver,A Valle,R Guevara,FJ ,P Roca,J Oliver,

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Sexual dimorphism in liver mitochondrial oxidative capacity is conserved under caloric restriction conditions. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Cell physiology

VOLUME: 293

Page Numbers: C1302-8

Journal Abbreviation: Am. J. Physiol., Cell Physiol.

ISSN: 0363-6143

DAY: 25

MONTH: 07

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 100901225

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AFFILIATION: Grup de Metabolisme Energètic i Nutrició, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, E-07122, Palma de Mallorca, Spain.

Country: United States

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MEDLINETA: Am J Physiol Cell Physiol

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