Sex-specific differences in leg fat uptake are revealed with a high-fat meal.

Sex-specific differences in leg fat uptake are revealed with a high-fat meal. Research Abstract Details 

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Sex-specific differences in leg fat uptake are revealed with a high-fat meal. Abstract Text:

Susanne B Votruba,Michael D Jensen,

The mechanism(s) by which sex specific differences in regional body fat distribution develop are not known. We assessed the effects of a high-fat (HF) meal on fatty acid oxidation and uptake into regional fat depots using isotopic tracers and adipose biopsies. Thirty men (BMI 23.6 +/- 0.3 kg/m(2)) and 29 women (BMI 22.4 +/- 0.3 kg/m(2)) received a meal containing [(3)H]triolein. Twelve of the men and 13 of the women received an additional 80 g of triolein in the meal (HF) and the remainder received a normal-fat (NF) meal. Adipose tissue lipoprotein lipase (LPL) activity was measured in the fed and fasted state. After 24 h, meal fatty acid uptake into subcutaneous adipose tissue was assessed. The efficiency of meal fat uptake into upper body subcutaneous fat was similar in both sexes, but women had a greater leg fat uptake, especially in response to a HF meal (P < 0.0001). A correlation between fed-state LPL activity and meal fat uptake was found in both upper and lower body fat (P < 0.0001, r = 0.69). These studies show that, in times of net fat storage, women preferentially increase uptake in leg adipose tissue, and this is likely mediated by fed-state LPL activity.

Sex-specific differences in leg fat uptake are revealed with a high-fat meal. Publishing Authors By Initials

SB Votruba,MD Jensen,

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Sex-specific differences in leg fat uptake are revealed with a high-fat meal. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Endocrinology and

VOLUME: 291

Page Numbers: E1115-23

Journal Abbreviation: Am. J. Physiol. Endocrinol. Me

ISSN: 0193-1849

DAY: 27

MONTH: 06

YEAR: 2006

Sex-specific differences in leg fat uptake are revealed with a high-fat meal. Information

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LANGUAGE: eng

NlmUniqueID: 100901226

Sex-specific differences in leg fat uptake are revealed with a high-fat meal. Keywords Mesh Terms:

KEYWORDS: Tritium

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Sex-specific differences in leg fat uptake are revealed with a high-fat meal. Information

Substance Name: Lipoprotein Lipase

Registry Number: EC 3.1.1.34

Grant and Affiliation Information for Sex-specific differences in leg fat uptake are revealed with a high-fat meal.

AFFILIATION: Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR-0585

ACRONYM: RR

MEDLINETA: Am J Physiol Endocrinol Metab

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