Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic.

Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic. Research Abstract Details 

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Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic. Abstract Text:

Michael Lever,Wendy Atkinson,Peter M George,Stephen T Chambers,Michael Lever,Wendy Atkinson,Peter M George,Stephen T Chambers,

OBJECTIVES: To find whether the control of betaine metabolism differs between male and female patients and identify the effects of insulin and other hormones. DESIGN AND METHODS: Data from non-diabetic lipid clinic patients (82 female symbol and 76 male symbol) were re-analyzed by sex. Data on insulin, thyroid hormones and leptin were included in models to identify factors affecting the circulation and excretion of betaine and its metabolites. RESULTS: Different factors influenced plasma concentrations and urinary excretion of betaine, dimethylglycine and homocysteine in males and females. In males, apolipoprotein B (negative), thyroid stimulating hormone (positive) and insulin (negative) predicted circulating betaine, consistent with betaine-homocysteine methyltransferase mediated control. In females, insulin positively predicted plasma dimethylglycine. Urinary betaine excretion positively predicted circulating homocysteine in males (p<0.001), whereas dimethylglycine excretion (also indicating betaine loss) was a stronger positive predictor (p<0.001) in females. Carnitine affected betaine homeostasis. CONCLUSIONS: Betaine metabolism is under endocrine control, and studies should use sex stratified groups.

Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic. Publishing Authors By Initials

M Lever,W Atkinson,PM George,ST Chambers,M Lever,W Atkinson,PM George,ST Chambers,

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Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical biochemistry

VOLUME: 40

Page Numbers: 1225-31

Journal Abbreviation: Clin. Biochem.

ISSN: 0009-9120

DAY: 17

MONTH: 07

YEAR: 2007

Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic. Information

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LANGUAGE: eng

NlmUniqueID: 133660

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AFFILIATION: Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand. michael.lever@chmeds.ac.nz

Country: United States

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MEDLINETA: Clin Biochem

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