Sex differences in severe pulmonary emphysema.

Sex differences in severe pulmonary emphysema. Research Abstract Details 

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Sex differences in severe pulmonary emphysema. Abstract Text:

RATIONALE: Limited data on sex differences in advanced COPD are available. OBJECTIVES: To compare male and female emphysema patients with severe disease. METHODS: One thousand fifty-three patients (38.8% female) evaluated for lung volume reduction surgery as part of the National Emphysema Treatment Trial were analyzed. MEASUREMENTS AND MAIN RESULTS: Detailed clinical, physiological, and radiological assessment, including quantitation of emphysema severity and distribution from helical chest computed tomography, was completed. In a subgroup (n = 101), airway size and thickness was determined by histological analyses of resected tissue. Women were younger and exhibited a lower body mass index (BMI), shorter smoking history, less severe airflow obstruction, lower Dl(co) and arterial Po(2), higher arterial Pco(2), shorter six-minute walk distance, and lower maximal wattage during oxygen-supplemented cycle ergometry. For a given FEV(1)% predicted, age, number of pack-years, and proportion of emphysema, women experienced greater dyspnea, higher modified BODE, more depression, lower SF-36 mental component score, and lower quality of well-being. Overall emphysema was less severe in women, with the difference from men most evident in the outer peel of the lung. Females had thicker small airway walls relative to luminal perimeters. CONCLUSIONS: In patients with severe COPD, women, relative to men, exhibit anatomically smaller airway lumens with disproportionately thicker airway walls, and emphysema that is less extensive and characterized by smaller hole size and less peripheral involvement.

Sex differences in severe pulmonary emphysema. Publishing Authors By Initials

For similar epidemiologic factors: sex factors research abstracts see: epidemiologic factors: sex factors research

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Sex differences in severe pulmonary emphysema. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of respiratory and critical care

VOLUME: 176

Page Numbers: 243-52

Journal Abbreviation: Am. J. Respir. Crit. Care Med.

ISSN: 1073-449X

DAY: 12

MONTH: 04

YEAR: 2007

Sex differences in severe pulmonary emphysema. Information

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LANGUAGE: eng

NlmUniqueID: 9421642

Sex differences in severe pulmonary emphysema. Keywords Mesh Terms:

KEYWORDS: Sex Factors

MESH TERMS: psychology

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Grant and Affiliation Information for Sex differences in severe pulmonary emphysema.

AFFILIATION: University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, Michigan 48109-0360, USA. Fmartine@umich.edu

Country: United States

AGENCY: United States NHLBI

GRANT: N01HR76119

ACRONYM: HR

MEDLINETA: Am J Respir Crit Care Med

REFSOURCE: Am J Respir Crit Care Med. 2007 Aug 1;17

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