Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation.

Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation. Research Abstract Details 

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Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation. Abstract Text:

Meijing Wang,Wenjun Zhang,Paul Crisostomo,Troy Markel,Kirstan K Meldrum,Xin Y Fu,Daniel R Meldrum,

Recent studies have shown that females have improved myocardial functional recovery, TNF receptor 1 (TNFR1) signaling resistance, and increased STAT3 phosphorylation following acute ischemia/reperfusion (I/R) compared with males. We hypothesized that 1) STAT3 deficiency in endothelial cells (EC) impairs myocardial functional recovery in both sexes, 2) EC STAT3 deficiency equalizes sex differences in functional recovery, and 3) knockout of EC STAT3 decreases activation of myocardial STAT3 and increases p38 MAPK activation following acute I/R. Isolated male and female mouse hearts from WT and EC STAT3 knockout (STAT3KO) were subjected to 20-min ischemia/60-min reperfusion, and +/- dP/dt were continuously recorded. Heart tissue was analyzed for the active forms of STAT3 and p38 MAPK as well as expression of caspase-8 (Western blot) following I/R. EC STATKO had significantly decreased myocardial functional recovery in both sexes (%recovered +dP/dt: male 51.6 +/- 3.1 vs. 32.1 +/- 13.1%, female 79.1 +/- 3.6 vs. 43.6 +/- 9.1%; -dP/dt: male 52.2 +/- 3.3 vs. 28.9 +/- 12%, female 75.2 +/- 4.1 vs. 38.6 +/- 10%). In addition, EC STAT3KO neutralized sex differences in myocardial function, which existed in WT mice. Interestingly, EC STAT3 deficiency decreased myocardial STAT3 activation but increased myocardial p38 MAPK activation in both sexes; however, this was seen to a greater degree in females. We conclude that EC STAT3 deficiency resulted in decreased recovery of myocardial function in both sexes and neutralized sex differences in myocardial functional recovery following I/R. This observation was associated with decreased activation of myocardial STAT3 and increased activation of p38 MAPK in EC STAT3KO heart after I/R.

Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation. Publishing Authors By Initials

M Wang,W Zhang,P Crisostomo,T Markel,KK Meldrum,XY Fu,DR Meldrum,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: mitogen-activated protein kinases: p38 mitogen-activated protein kinases research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: mitogen-activated protein kinases: p38 mitogen-activated protein kinases research

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Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Endocrinology and

VOLUME: 293

Page Numbers: E872-7

Journal Abbreviation: Am. J. Physiol. Endocrinol. Me

ISSN: 0193-1849

DAY: 26

MONTH: 06

YEAR: 2007

Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation. Information

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LANGUAGE: eng

NlmUniqueID: 100901226

Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation. Keywords Mesh Terms:

KEYWORDS: p38 Mitogen-Activated Protein Kinases

MESH TERMS: metabolism

Chemical & Substance for Abstract: Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation. Information

Substance Name: p38 Mitogen-Activated Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Sex differences in endothelial STAT3 mediate sex differences in myocardial inflammation.

AFFILIATION: Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01-GM-070628

ACRONYM: GM

MEDLINETA: Am J Physiol Endocrinol Metab

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