Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels: Hypoxic Regulation via Transforming Growth Factor- 3.

Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels: Hypoxic Regulation via Transforming Growth Factor- 3. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels: Hypoxic Regulation via Transforming Growth Factor- 3. Abstract Text:

Yoav Yinon,Ori Nevo,Jing Xu,Ariel Many,Alessandro Rolfo,Tullia Todros,Martin Post,Isabella Caniggia,Yoav Yinon,Ori Nevo,Jing Xu,Ariel Many,Alessandro Rolfo,Tullia Todros,Martin Post,Isabella Caniggia,Yoav Yinon,Ori Nevo,Jing Xu,Ariel Many,Alessandro Rolfo,Tullia Todros,Martin Post,Isabella Caniggia,

Endoglin, a co-receptor for transforming growth factor (TGF)-beta(1) and -beta(3) is expressed in the human placenta and plays an important role in the pathogenesis of preeclampsia. Because preeclampsia is associated with hypoxia, and because TGF-beta3 is overexpressed in preeclamptic pregnancies, we examined the effect of oxygen and TGF-beta3 on placental endoglin expression and investigated its expression in pathological models of placental hypoxia such as intrauterine growth restriction (IUGR) pregnancies. Endoglin expression was high at 4 to 9 weeks of gestation, when oxygen tension is low, and decreased after 10 weeks, when oxygen tension increases. Exposure of villous explants to low oxygen (3% O(2)) resulted in elevated expression of both membrane and soluble endoglin compared to standard conditions (20% O(2)). Moreover, addition of TGF-beta(3) to villous explants under low oxygen conditions increased the expression of endoglin compared to nontreated explants whereas addition of TGF-beta(3)-neutralizing antibodies inhibited the low oxygen stimulatory effect on endoglin expression. Endoglin and soluble endoglin expression were significantly increased in placentas of IUGR singletons compared to controls and in the IUGR twin placentas relative to both the control co-twin and the normal twins. These data demonstrate that oxygen regulates the placental expression of endoglin via TGF-beta(3). Reduced placental perfusion leading to placental hypoxia might contribute to the increased expression of endoglin in IUGR pregnancies.

Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels: Hypoxic Regulation via Transforming Growth Factor- 3. Publishing Authors By Initials

Y Yinon,O Nevo,J Xu,A Many,A Rolfo,T Todros,M Post,I Caniggia,Y Yinon,O Nevo,J Xu,A Many,A Rolfo,T Todros,M Post,I Caniggia,Y Yinon,O Nevo,J Xu,A Many,A Rolfo,T Todros,M Post,I Caniggia,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels: Hypoxic Regulation via Transforming Growth Factor- 3. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The American journal of pathology

VOLUME: 172

Page Numbers: 77-85

Journal Abbreviation: Am. J. Pathol.

ISSN: 0002-9440

DAY: 21

MONTH: 12

YEAR: 2007

Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels: Hypoxic Regulation via Transforming Growth Factor- 3. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370502

Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels: Hypoxic Regulation via Transforming Growth Factor- 3. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels: Hypoxic Regulation via Transforming Growth Factor- 3. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels: Hypoxic Regulation via Transforming Growth Factor- 3.

AFFILIATION: Mount Sinai Hospital, Samuel Lunenfeld Research Institute, 600 University Ave., Room 871c, Toronto, Ontario, Canada M5G 1X5. caniggia@mshri.on.ca.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Am J Pathol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels: Hypoxic Regulation via Transforming Growth Factor- 3 Related Publications

• Hypoxic switch in mitochondrial myeloid cell leukemia factor-1/Mtd apoptotic rheostat contributes to human trophoblast cell death in preeclampsia.
• Placental Expression of Soluble fms-Like Tyrosine Kinase 1 is Increased in Singletons and Twin Pregnancies with Intrauterine Growth Restriction.
• Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels: Hypoxic Regulation via Transforming Growth Factor- 3.