Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection.

Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Research Abstract Details 

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Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Abstract Text:

Vincent C C Cheng,Susanna K P Lau,Patrick C Y Woo,Kwok Yung Yuen,

Before the emergence of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) in 2003, only 12 other animal or human coronaviruses were known. The discovery of this virus was soon followed by the discovery of the civet and bat SARS-CoV and the human coronaviruses NL63 and HKU1. Surveillance of coronaviruses in many animal species has increased the number on the list of coronaviruses to at least 36. The explosive nature of the first SARS epidemic, the high mortality, its transient reemergence a year later, and economic disruptions led to a rush on research of the epidemiological, clinical, pathological, immunological, virological, and other basic scientific aspects of the virus and the disease. This research resulted in over 4,000 publications, only some of the most representative works of which could be reviewed in this article. The marked increase in the understanding of the virus and the disease within such a short time has allowed the development of diagnostic tests, animal models, antivirals, vaccines, and epidemiological and infection control measures, which could prove to be useful in randomized control trials if SARS should return. The findings that horseshoe bats are the natural reservoir for SARS-CoV-like virus and that civets are the amplification host highlight the importance of wildlife and biosecurity in farms and wet markets, which can serve as the source and amplification centers for emerging infections.

Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Publishing Authors By Initials

VC Cheng,SK Lau,PC Woo,KY Yuen,

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Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Journal Published:

PUBLICATION TYPE: Review

Journal: Clinical microbiology reviews

VOLUME: 20

Page Numbers: 660-94

Journal Abbreviation: Clin. Microbiol. Rev.

ISSN: 0893-8512

DAY: 26

MONTH: Oct

YEAR: 2007

Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Information

Number of References: 434

LANGUAGE: eng

NlmUniqueID: 8807282

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Grant and Affiliation Information for Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection.

AFFILIATION: State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administrative Region, China.

Country: United States

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MEDLINETA: Clin Microbiol Rev

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