Seven-day artificial lung testing in an in-parallel configuration.

Seven-day artificial lung testing in an in-parallel configuration. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Seven-day artificial lung testing in an in-parallel configuration. Abstract Text:

Hitoshi Sato,Grant W Griffith,Candice M Hall,John M Toomasian,Ronald B Hirschl,Robert H Bartlett,Keith E Cook,

BACKGROUND: A thoracic artificial lung, the MC3 Biolung, is being developed as a bridge to lung transplantation or as a treatment for acute respiratory insufficiency. METHODS: The thoracic artificial lung was tested in 10 sheep with the goal of 7 days of respiratory support. The sheep were recovered from surgery and monitored awake for 7 days. Hemodynamics, blood gases, blood cell counts, and organ function were recorded, and after 7 days, all sheep were euthanized and necropsied. RESULTS: Seven sheep survived the full duration. Cardiac output and mean arterial blood pressure were unchanged, averaging 4.7 +/- 0.8 L/min and 98 +/- 10 mm Hg, respectively. Arterial oxygen tension and device oxygen transfer rate were also unchanged, averaging 110 +/- 26 mm Hg and 97.7 +/- 35 mL/min, respectively. Arterial carbon dioxide tension was within normal ranges during the entire experiment, averaging 37.4 +/- 3.8 mm Hg. Artificial lung blood flow decreased from 51% +/- 14% of cardiac output on day 1 to 30% +/- 16% by day 7 because of changes in natural and artificial lung resistance. White blood cell counts were significantly elevated on days 5 and 7, and lastly, kidney and liver function remained normal, although signs of kidney infarction or hemorrhage were noted. CONCLUSIONS: The thoracic artificial lung is suitable for 7-day attachment, but improvements in blood biocompatibility are warranted.

Seven-day artificial lung testing in an in-parallel configuration. Publishing Authors By Initials

H Sato,GW Griffith,CM Hall,JM Toomasian,RB Hirschl,RH Bartlett,KE Cook,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

PUBMED ID PMID:

MEDLINE DATE:

Seven-day artificial lung testing in an in-parallel configuration. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Annals of thoracic surgery

VOLUME: 84

Page Numbers: 988-94

Journal Abbreviation: Ann. Thorac. Surg.

ISSN: 1552-6259

DAY: 3

MONTH: Sep

YEAR: 2007

Seven-day artificial lung testing in an in-parallel configuration. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 15030100

Seven-day artificial lung testing in an in-parallel configuration. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: Seven-day artificial lung testing in an in-parallel configuration. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Seven-day artificial lung testing in an in-parallel configuration.

AFFILIATION: Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.

Country: Netherlands

AGENCY: United States NHLBI

GRANT: R01 HL69420

ACRONYM: HL

MEDLINETA: Ann Thorac Surg

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Seven-day artificial lung testing in an in-parallel configuration Related Publications

• 449.
• 5-HTTLPR Genotype-Specific Phenotype in Children and Adolescents With Autism.
• A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae.
• A prospective, open-label trial of memantine in the treatment of cognitive, behavioral, and memory dysfunction in pervasive developmental disorders.
• An intracrine view of angiogenesis.
• Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents.
• Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism.
• Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression.
• Characterization and in vitro degradation of salicylate-derived poly(anhydride-ester microspheres).
• Chronic glaucoma case finding and treatment in rural Africa: some questions and answers.
• Complete kinetic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
• Conformational analysis of the cis- and trans-adducts of the Pictet - Spengler reaction. Evidence for the structural basis for the C(1) - N(2) scission process in the cis- to trans-isomerization.
• Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins.
• Effect of Medicaid Managed Care on racial disparities in health care access.
• First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A.
• Genes expressed by both mesangial cells and bone marrow-derived cells underlie genetic susceptibility to crescentic glomerulonephritis in the rat.
• How to improve the outcome of cataract surgery.
• ITGB3 shows genetic and expression interaction with SLC6A4.
• Improving point predictions of random effects for subjects at high risk.
• Imputation strategies for blood pressure data nonignorably missing due to medication use.
• Monitoring cataract surgical outcomes: 'hand written' registration method.
• Oxidation artifacts in the electrospray mass spectrometry of Abeta Peptide.
• Pharmacological studies with a nonpeptidic, delta-opioid (-)-(1R,5R,9R)-5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride ((-)-NIH 11082).
• Preventing alcohol-exposed pregnancies.
• Remarkably mild and efficient intramolecular Friedel-Crafts cyclization catalyzed by In(III).
• The effects of dietary protein on age and weight at the onset of puberty in Brown Swiss and Zebu heifers in the tropics.
• The molecular mechanisms responsible for resistance in plant-pathogen interactions of the gene-for-gene type function more broadly than previously imagined.
• Tremor/ataxia syndrome and fragile X premutation: diagnostic caveats.
• Walking stride variability on different walking surfaces: 849: june 1 2:00 PM - 2:15 PM.
• rasiRNAs, DNA damage, and embryonic axis specification.