Setting a minimum threshold CD4 count for initiation of highly active antiretroviral therapy in HIV-infected patients.

Setting a minimum threshold CD4 count for initiation of highly active antiretroviral therapy in HIV-infected patients. Research Abstract Details 

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Setting a minimum threshold CD4 count for initiation of highly active antiretroviral therapy in HIV-infected patients. Abstract Text:

Cf Ho,Ss Lee,Kh Wong,Ls Cheng,My Lam,Cf Ho,Ss Lee,Kh Wong,Ls Cheng,My Lam,

The aim of our study was to determine a minimum threshold CD4 count for highly active antiretroviral therapy (HAART) initiation in HIV-infected patients. A schema using longitudinal data from a clinical cohort was designed. The presenting CD4 counts of asymptomatic HIV-infected patients in Hong Kong were evaluated in relation to their progression to AIDS within 1 year of diagnosis of HIV infection. A graph was generated to depict the changes in the percentage of cumulative AIDS diagnoses for every 10 cell/microL increase in presenting CD4 count. Of 181 patients, 24 had developed AIDS within 1 year of diagnosis of HIV infection. Setting the CD4 count threshold at 150 cells/microL gave a good balance between the number of preventable AIDS-defining events and the number of non-AIDS patients initiating HAART. No extra AIDS-defining events occurred when the CD4 count threshold was reduced from 200 to 150 cells/microL, despite the addition of 13 more patients. In multivariate Cox regression analysis, presenting CD4 count was a significant predictor for AIDS occurrence. The relative hazard for AIDS occurrence of patients with presenting CD4 counts

Setting a minimum threshold CD4 count for initiation of highly active antiretroviral therapy in HIV-infected patients. Publishing Authors By Initials

C Ho,S Lee,Kh Wong,L Cheng,M Lam,C Ho,S Lee,Kh Wong,L Cheng,M Lam,

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Setting a minimum threshold CD4 count for initiation of highly active antiretroviral therapy in HIV-infected patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: HIV medicine

VOLUME: 8

Page Numbers: 181-5

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ISSN: 1464-2662

DAY: 27

MONTH: Apr

YEAR: 2007

Setting a minimum threshold CD4 count for initiation of highly active antiretroviral therapy in HIV-infected patients. Information

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LANGUAGE: eng

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AFFILIATION: Integrated Treatment Centre, Centre for Health Protection, Department of Health, Kowloon, Hong Kong SAR, Hong Kong. cfho@dhspp.net

Country: England

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MEDLINETA: HIV Med

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