Sesquiterpene Lactones from the Roots of Ferula varia and Their Cytotoxic Activity.

Sesquiterpene Lactones from the Roots of Ferula varia and Their Cytotoxic Activity. Research Abstract Details 

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Sesquiterpene Lactones from the Roots of Ferula varia and Their Cytotoxic Activity. Abstract Text:

Kyoko Suzuki,Mamoru Okasaka,Yoshiki Kashiwada,Yoshihisa Takaishi,Gisho Honda,Michiho Ito,Yoshio Takeda,Olimjon K Kodzhimatov,Ozodbek Ashurmetov,Michiko Sekiya,Yasumasa Ikeshiro,Kyoko Suzuki,Mamoru Okasaka,Yoshiki Kashiwada,Yoshihisa Takaishi,Gisho Honda,Michiho Ito,Yoshio Takeda,Olimjon K Kodzhimatov,Ozodbek Ashurmetov,Michiko Sekiya,Yasumasa Ikeshiro,

The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones ( 1- 6) and five known sesquiterpenes ( 7- 11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1- 11 were evaluated against selected human cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine.

Sesquiterpene Lactones from the Roots of Ferula varia and Their Cytotoxic Activity. Publishing Authors By Initials

K Suzuki,M Okasaka,Y Kashiwada,Y Takaishi,G Honda,M Ito,Y Takeda,OK Kodzhimatov,O Ashurmetov,M Sekiya,Y Ikeshiro,K Suzuki,M Okasaka,Y Kashiwada,Y Takaishi,G Honda,M Ito,Y Takeda,OK Kodzhimatov,O Ashurmetov,M Sekiya,Y Ikeshiro,

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Sesquiterpene Lactones from the Roots of Ferula varia and Their Cytotoxic Activity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of natural products

VOLUME: 70

Page Numbers: 1915-8

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ISSN: 0163-3864

DAY: 4

MONTH: 12

YEAR: 2007

Sesquiterpene Lactones from the Roots of Ferula varia and Their Cytotoxic Activity. Information

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LANGUAGE: eng

NlmUniqueID: 7906882

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AFFILIATION: takaishi@ph.tokushima-u.ac.jp.

Country: United States

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MEDLINETA: J Nat Prod

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