Serum withdrawal-induced apoptosis in ZrchI prion protein (PrP) gene-deficient neuronal cell line is suppressed by PrP, independent of Doppel.

Serum withdrawal-induced apoptosis in ZrchI prion protein (PrP) gene-deficient neuronal cell line is suppressed by PrP, independent of Doppel. Research Abstract Details 

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Serum withdrawal-induced apoptosis in ZrchI prion protein (PrP) gene-deficient neuronal cell line is suppressed by PrP, independent of Doppel. Abstract Text:

Takuya Nishimura,Akikazu Sakudo,Yoriko Hashiyama,Akiko Yachi,Keiichi Saeki,Yoshitsugu Matsumoto,Masaharu Ogawa,Suehiro Sakaguchi,Shigeyoshi Itohara,Takashi Onodera,Takuya Nishimura,Akikazu Sakudo,Yoriko Hashiyama,Akiko Yachi,Keiichi Saeki,Yoshitsugu Matsumoto,Masaharu Ogawa,Suehiro Sakaguchi,Shigeyoshi Itohara,Takashi Onodera,

Previous studies have shown that cellular prion protein (PrP(C)) plays anti-apoptotic and antioxidative role against cell death induced by serum-deprivation (SDP) in an immortalized prion protein gene-deficient neuronal cell line derived from Rikn prion protein (PrP) gene-deficient (Prnp(-/-)) mice, which ectopically produce excess Doppel (Dpl) (PrP-like glycoprotein). To investigate whether PrP(C) inhibits apoptotic neuronal cell death without Dpl, an immortalized cell line was established from the brain of ZrchI Prnp(-/-) mice, which do not show ectopic expression of Dpl. The results using a ZrchI neuronal Prnp(-/-) cell line (NpL2) showed that PrP(C) potently inhibited SDP-induced apoptotic cell death. Furthermore, PrP(C) expression enhanced the superoxide dismutase (SOD) activity in NpL2 cells. These results indicate that Dpl production did not affect anti-apoptotic and anti-oxidative functions of PrP, suggesting that PrP(C) may be directly correlated with protection against oxidative stress.

Serum withdrawal-induced apoptosis in ZrchI prion protein (PrP) gene-deficient neuronal cell line is suppressed by PrP, independent of Doppel. Publishing Authors By Initials

T Nishimura,A Sakudo,Y Hashiyama,A Yachi,K Saeki,Y Matsumoto,M Ogawa,S Sakaguchi,S Itohara,T Onodera,T Nishimura,A Sakudo,Y Hashiyama,A Yachi,K Saeki,Y Matsumoto,M Ogawa,S Sakaguchi,S Itohara,T Onodera,

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Serum withdrawal-induced apoptosis in ZrchI prion protein (PrP) gene-deficient neuronal cell line is suppressed by PrP, independent of Doppel. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Microbiology and immunology

VOLUME: 51

Page Numbers: 457-66

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ISSN: 0385-5600

DAY: 20

MONTH: 04

YEAR: 2007

Serum withdrawal-induced apoptosis in ZrchI prion protein (PrP) gene-deficient neuronal cell line is suppressed by PrP, independent of Doppel. Information

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LANGUAGE: eng

NlmUniqueID: 7703966

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Grant and Affiliation Information for Serum withdrawal-induced apoptosis in ZrchI prion protein (PrP) gene-deficient neuronal cell line is suppressed by PrP, independent of Doppel.

AFFILIATION: Department of Molecular Immunology, School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan.

Country: Japan

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MEDLINETA: Microbiol Immunol

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