Serum soluble nucleosome and the broad family of antinucleosome antibodies are associated with organ and tissue damage in systemic lupus erythematosus in a Chinese population.

Serum soluble nucleosome and the broad family of antinucleosome antibodies are associated with organ and tissue damage in systemic lupus erythematosus in a Chinese population. Research Abstract Details 

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Serum soluble nucleosome and the broad family of antinucleosome antibodies are associated with organ and tissue damage in systemic lupus erythematosus in a Chinese population. Abstract Text:

O Wu,H H Liu,W X Li,N Zhang,Q Wang,X P Li,M X Dong,X J Zhang,D Q Ye,

Nucleosomes and the broad family of antinucleosome antibodies (ANAs; anti-double-stranded DNA, antihistone and antinucleosome antibodies) may contribute to the pathogenesis of systemic lupus erythematosus (SLE). We collected clinical information on 90 patients with SLE and 73 healthy volunteers and measured serum levels of the ANA family using a double-sandwich ELISA. The results showed that the levels of serum nucleosomes of patients with SLE was significantly lower and the levels of ANA were significantly higher than healthy controls. Negative correlations between serum nucleosomes and ANA, and positive correlations between individual ANAs were found. Patients with SLE with positive ANA had a significantly higher frequency of renal disorders than those with negative ANA. Determination of serum nucleosomes and ANAs contributes to SLE monitoring.

Serum soluble nucleosome and the broad family of antinucleosome antibodies are associated with organ and tissue damage in systemic lupus erythematosus in a Chinese population. Publishing Authors By Initials

O Wu,HH Liu,WX Li,N Zhang,Q Wang,XP Li,MX Dong,XJ Zhang,DQ Ye,

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Serum soluble nucleosome and the broad family of antinucleosome antibodies are associated with organ and tissue damage in systemic lupus erythematosus in a Chinese population. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental dermatology

VOLUME: 33

Page Numbers: 160-3

Journal Abbreviation: Clin. Exp. Dermatol.

ISSN: 0307-6938

DAY: 8

MONTH: Mar

YEAR: 2008

Serum soluble nucleosome and the broad family of antinucleosome antibodies are associated with organ and tissue damage in systemic lupus erythematosus in a Chinese population. Information

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LANGUAGE: eng

NlmUniqueID: 7606847

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Grant and Affiliation Information for Serum soluble nucleosome and the broad family of antinucleosome antibodies are associated with organ and tissue damage in systemic lupus erythematosus in a Chinese population.

AFFILIATION: Department of Epidemiology and Biostatistics, Anhui Medical University, Anhui, China.

Country: England

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MEDLINETA: Clin Exp Dermatol

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