Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus.

Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. Research Abstract Details 

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Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. Abstract Text:

Joseph M Miano,Xiaochun Long,Keigi Fujiwara,

Serum response factor (SRF) is a highly conserved and widely expressed, single copy transcription factor that theoretically binds up to 1,216 permutations of a 10-base pair cis element known as the CArG box. SRF-binding sites were defined initially in growth-related genes. Gene inactivation or knockdown studies in species ranging from unicellular eukaryotes to mice have consistently shown loss of SRF to be incompatible with life. However, rather than being critical for proliferation and growth, these genetic studies point to a crucial role for SRF in cellular migration and normal actin cytoskeleton and contractile biology. In fact, recent genomic studies reveal nearly half of the >200 SRF target genes encoding proteins with functions related to actin dynamics, lamellipodial/filopodial formation, integrin-cytoskeletal coupling, myofibrillogenesis, and muscle contraction. SRF has therefore emerged as a dispensable transcription factor for cellular growth but an absolutely essential orchestrator of actin cytoskeleton and contractile homeostasis. This review summarizes the recent genomic and genetic analyses of CArG-SRF that support its role as an ancient, master regulator of the actin cytoskeleton and contractile machinery.

Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. Publishing Authors By Initials

JM Miano,X Long,K Fujiwara,

For similar proteins: dna-binding proteins: homeodomain proteins: mads domain proteins: serum response factor research abstracts see: proteins: dna-binding proteins: homeodomain proteins: mads domain proteins: serum response factor research

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Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. Journal Published:

PUBLICATION TYPE: Review

Journal: American journal of physiology. Cell physiology

VOLUME: 292

Page Numbers: C70-81

Journal Abbreviation: Am. J. Physiol., Cell Physiol.

ISSN: 0363-6143

DAY: 23

MONTH: 08

YEAR: 2006

Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. Information

Number of References: 126

LANGUAGE: eng

NlmUniqueID: 100901225

Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. Keywords Mesh Terms:

KEYWORDS: Serum Response Factor

MESH TERMS: physiology

Chemical & Substance for Abstract: Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. Information

Substance Name: Serum Response Factor

Registry Number: 0

Grant and Affiliation Information for Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus.

AFFILIATION: Cardiovascular Research Institute, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA. j.m.miano@rochester.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL 70077

ACRONYM: HL

MEDLINETA: Am J Physiol Cell Physiol

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