Serum resistin concentrations in growth hormone-deficient children during growth hormone replacement therapy.

Serum resistin concentrations in growth hormone-deficient children during growth hormone replacement therapy. Research Abstract Details 

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Serum resistin concentrations in growth hormone-deficient children during growth hormone replacement therapy. Abstract Text:

Hiroki Nozue,Tomohiro Kamoda,Akira Matsui,Hiroki Nozue,Tomohiro Kamoda,Akira Matsui,

We performed this study to examine whether the serum resistin concentrations in growth hormone (GH)-deficient (GHD) children are influenced by administration of GH and to assess the relationship between serum resistin and free fatty acid levels during GH replacement therapy. The study included 20 prepubertal GHD children (16 boys and 4 girls) who were treated with recombinant human GH (hGH). The serum levels of resistin, insulin-like growth factor I, free fatty acid (FFA), triglyceride, cholesterol and glucose levels, leukocyte counts, and hemoglobin A(1c) were measured at baseline and after 1 month of hGH treatment. The serum resistin levels after hGH therapy were significantly higher than the basal resistin levels (median [range], 6.2 [4.9-11.8] vs 5.6 [4.4-8.3] ng/mL; P < .05), whereas the serum FFA levels were unchanged before and after treatment (0.51 [0.34-0.76] vs 0.37 [0.24-0.60] mEq/L). No significant relationship was found between serum resistin and FFA levels after hGH therapy. Body mass index, serum triglyceride, cholesterol and glucose levels, leukocyte counts, and hemoglobin A(1c) showed no significant differences before and after hGH treatment. Our results suggest that elevated serum resistin levels after 1-month hGH therapy in GHD children are not associated with the GH-induced lipolysis as found in GHD adults during short-time hGH therapy.

Serum resistin concentrations in growth hormone-deficient children during growth hormone replacement therapy. Publishing Authors By Initials

H Nozue,T Kamoda,A Matsui,H Nozue,T Kamoda,A Matsui,

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Serum resistin concentrations in growth hormone-deficient children during growth hormone replacement therapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Metabolism: clinical and experimental

VOLUME: 56

Page Numbers: 1514-7

Journal Abbreviation: Metab. Clin. Exp.

ISSN: 0026-0495

DAY: 22

MONTH: Nov

YEAR: 2007

Serum resistin concentrations in growth hormone-deficient children during growth hormone replacement therapy. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pediatrics, Tsukuba Medical Center Hospital, Ibaraki 305-8558, Japan. nozueh@xd5.so-net.ne.jp

Country: United States

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MEDLINETA: Metabolism

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