Serum prolactin levels and immunohistochemical localization of prolactin in trophoblastic disease.

Serum prolactin levels and immunohistochemical localization of prolactin in trophoblastic disease. Research Abstract Details 

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Serum prolactin levels and immunohistochemical localization of prolactin in trophoblastic disease. Abstract Text:

T Ranta,T Wahlström,E M Rutanen,U H Stenman,M Seppälä,

The circulating levels of chorionic gonadotropin, pregnancy specific beta-I-glycoprotein, prolactin and oestradiol were estimated by radioimmunoassay in 219 serum samples from 18 patients with choriocarcinoma and 45 samples from 8 patients with hydatidiform mole. Prolactin and oestradiol concentrations were higher in samples which also contained trophoblastic markers. This difference was also seen in patients with choriocarcinoma and it was not due to chemotherapy, since the difference between hCG positive and hCG negative samples was maintained during chemotherapy. Prolactin was found by immunoperoxidase technique in the syncytiotrophoblast of normal placenta throughout gestation, and also in hydatidiform mole, invasive mole and choriocarcinoma. It is suggested that the malignant syncytiotrophoblast may contribute to circulating prolactin levels either by direct secretion of prolactin or by oestrogen stimulation of the pituitary.

Serum prolactin levels and immunohistochemical localization of prolactin in trophoblastic disease. Publishing Authors By Initials

T Ranta,T Wahlström,EM Rutanen,UH Stenman,M Seppälä,

For similar neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, female: uterine neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, female: uterine neoplasms research

PUBMED ID PMID:

MEDLINE DATE:

Serum prolactin levels and immunohistochemical localization of prolactin in trophoblastic disease. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Acta pathologica et microbiologica Scandinavica. S

VOLUME: 89

Page Numbers: 235-9

Journal Abbreviation:

ISSN: 0365-4184

DAY: 20

MONTH: May

YEAR: 1981

Serum prolactin levels and immunohistochemical localization of prolactin in trophoblastic disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7508468

Serum prolactin levels and immunohistochemical localization of prolactin in trophoblastic disease. Keywords Mesh Terms:

KEYWORDS: Uterine Neoplasms

MESH TERMS: blood

Chemical & Substance for Abstract: Serum prolactin levels and immunohistochemical localization of prolactin in trophoblastic disease. Information

Substance Name: Prolactin

Registry Number: 9002-62-4

Grant and Affiliation Information for Serum prolactin levels and immunohistochemical localization of prolactin in trophoblastic disease.

AFFILIATION:

Country: DENMARK

AGENCY: United States NCI

GRANT: 1 R01 CA 23809-01

ACRONYM: CA

MEDLINETA: Acta Pathol Microbiol Scand [A

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